Azacitidine

Azacitidine

Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.

Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.


Brand name:Azacitidine

Active Ingeridents:Azacitidine

Company Name: Dr.Reddy’s

Package:Vial

Strength :100mg

Mechanism of action:

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.

Precaution:

  • Before starting Azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Azacitidine.

Store:

Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.

Warning:

Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

Dosage and Administration:

Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Azacitidine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Azacitidine at home, a health care provider will teach you how to use it. Be sure you understand how to use Azacitidine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Azacitidine if it contains particles, is discolored, or if the vial is cracked or damaged.
  • You may receive certain other medicines before Azacitidine to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.
  • Ask your health care provider any questions you may have about how to use Azacitidine.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Azacitidine

Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.

Azacitidine is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.


Brand name:Azacitidine

Active Ingeridents:Azacitidine

Company Name:Sandoz

Package:Vial

Strength :100mg

Mechanism of action:

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.

Precaution:

  • Before starting Azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Azacitidine.

Store:

Azacitidine is usually handled and stored by a health care provider. If you are using Azacitidine at home, store Azacitidine as directed by your pharmacist or health care provider. Keep Azacitidine out of the reach of children and away from pets.

Warning:

Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

Dosage and Administration:

Use Azacitidine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Azacitidine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Azacitidine at home, a health care provider will teach you how to use it. Be sure you understand how to use Azacitidine. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Azacitidine if it contains particles, is discolored, or if the vial is cracked or damaged.
  • You may receive certain other medicines before Azacitidine to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.
  • Ask your health care provider any questions you may have about how to use Azacitidine.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Vidaza

Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.

Vidaza(Azacitidine) is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.


Brand name:Vidaza

Active Ingeridents:Azacitidine

Company Name:Pharmion Corporation

Package:Vial

Strength :100mg

Mechanism of action:

Vidaza(Azacitidine) (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Vidaza(Azacitidine) is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Vidaza (Azacitidine) is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.

Precaution:

  • Before starting Vidaza (Azacitidine) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Vidaza (Azacitidine).

Store:

Vidaza (Azacitidine) is usually handled and stored by a health care provider. If you are using Vidaza (Azacitidine) at home, store Vidaza (Azacitidine) as directed by your pharmacist or health care provider. Keep Vidaza (Azacitidine) out of the reach of children and away from pets.

Warning:

Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

Dosage and Administration:

Use Vidaza (Azacitidine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Vidaza (Azacitidine) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Vidaza (Azacitidine) at home, a health care provider will teach you how to use it. Be sure you understand how to use Vidaza (Azacitidine). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Vidaza (Azacitidine) if it contains particles, is discolored, or if the vial is cracked or damaged.
  • You may receive certain other medicines before Vidaza (Azacitidine) to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.
  • Ask your health care provider any questions you may have about how to use Vidaza (Azacitidine).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.


Xpreza

Indication:

Treating certain blood problems, including chronic myelomonocytic leukemia. It may also be used for other conditions as determined by your doctor.

Xpreza(Azacitidine) is an antineoplastic. It works by causing the death of abnormal, rapidly dividing cells in the bone marrow.


Brand name:Xpreza

Active Ingeridents:Azacitidine

Company Name:Natco

Package:Vial

Strength :100mg

Mechanism of action:

Xpreza(Azacitidine) (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Xpreza(Azacitidine) is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As Xpreza (Azacitidine) is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.

Precaution:

  • Before starting Xpreza (Azacitidine) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
  • Do not receive any kind of immunization or vaccination without your doctor's approval while taking Xpreza (Azacitidine).

Store:

Xpreza (Azacitidine) is usually handled and stored by a health care provider. If you are using Xpreza (Azacitidine) at home, store Xpreza (Azacitidine) as directed by your pharmacist or health care provider. Keep Xpreza (Azacitidine) out of the reach of children and away from pets.

Warning:

Azacitidine is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.

Dosage and Administration:

Use Xpreza (Azacitidine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Xpreza (Azacitidine) is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Xpreza (Azacitidine) at home, a health care provider will teach you how to use it. Be sure you understand how to use Xpreza (Azacitidine). Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Xpreza (Azacitidine) if it contains particles, is discolored, or if the vial is cracked or damaged.
  • You may receive certain other medicines before Xpreza (Azacitidine) to help decrease the risk of nausea and vomiting. Discuss any questions with your doctor.
  • Ask your health care provider any questions you may have about how to use Xpreza (Azacitidine).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; constipation; cough; diarrhea; dizziness; dry skin; headache; indigestion; joint pain; loss of appetite; mild muscle pain; nausea; pain, swelling, or redness at the injection site; stomach tenderness; tiredness or weakness; trouble sleeping; vomiting.