This medicine is used to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Abacavir and lamivudine belong to a class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Dolutegravir belongs to a class of drugs known as integrase inhibitors.
Brand name: Triumeq
Active Ingeridents: Abacavir-Lamivudine-Dolutegravir
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.
Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Dolutegravir is an HIV-1 antiviral agent. It inhibits HIV integrase by binding to the active site and blocking the strand transfer step to retroviral DNA integration. This is an essential step of the HIV replication cycle and will result in an inhibition of viral activity. Dolutegravir has a mean EC50 value of 0.5 nM (0.21 ng/mL) to 2.1 nM (0.85 ng/mL) in peripheral blood mononuclear cells (PBMCs) and MT-4 cells.
Dosage and Administration:
Use Triumeq (Abacavir/ dolutegravir/ lamivudine) as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Triumeq (Abacavir/ dolutegravir/ lamivudine) comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Triumeq (Abacavir/ dolutegravir/ lamivudine) refilled.
Triumeq (Abacavir/ dolutegravir/ lamivudine) comes with a warning card that provides information about recognition of allergic reactions. Carry the warning card of allergy symptoms with you. Tell your health care provider immediately about any side effects you experience while taking Triumeq (Abacavir/ dolutegravir/ lamivudine).
Take Triumeq (Abacavir/ dolutegravir/ lamivudine) by mouth with or without food.
Do not take an antacid or product that has magnesium, aluminum, iron, or calcium; sucralfate; or buffered medicines within 6 hours before or 2 hours after you take Triumeq (Abacavir/ dolutegravir/ lamivudine).
Ask your health care provider any questions you may have about how to use Triumeq (Abacavir/ dolutegravir/ lamivudine).
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Headache; tiredness; trouble sleeping.
Store Triumeq (Abacavir/ dolutegravir/ lamivudine) in the original bottle at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep the bottle tightly closed. Do not remove the anti-moisture packet. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Triumeq (Abacavir/ dolutegravir/ lamivudine) out of the reach of children and away from pets.
Before taking this medication, tell your doctor or pharmacist if you are allergic to abacavir, dolutegravir, or lamivudine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Triumeq (Abacavir/ dolutegravir/ lamivudine) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.