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indication


Abalam tablet is indicated for the treatment of patients suffering from HIV type I infection patients.

Pharmacokinetic

Absorption

Abacavir and lamivudine is highly absorbed after oral administration and its bioavailability occurs at 83% and 87% respectively

Distribution

The drug Abacavir bound to human plasma protein nearly 50%; lamivudine has low plasma protein binding.

Metabolism

Abacavir metabolism occurred by alcohol dehydrogenase and glucuronyl transferase. Lamivudine is metabolized to trans-sulfoxide and biotransformation is catalyzed by sulfotransferases.

Elimination

The terminal half life of abacavir and lamivudine is 1.54±0.63 hours and 5 to 7 hours respectively. Lamivudine is excreted in human milk




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Brand : Abalam
Ingredients : Abacavir & Lamivudine
Strength : Abacavir 600mg & Lamivudine 300mg
Manufactured : Hetero
Package : 30 Tablets

Abalam dosage and administration

The usual dose of Abalam tablet is one tablet of abacavir 600mg nad 300mg Lamivudine, which to be taken orally as a single dose, in combination with other anti-retroviral medicines with or without food.

Abalam side effects

Fatal hypersensitivity reactions Lactic acidosis and severe hepatomegaly with steatosis Exacerbations of hepatitis B Hepatic decompensated in patients co-infected with HIV-I and hepatitis C Immune reconstitution syndrome Fat redistribution Myocardial infraction Some common side effects; Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety



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Abalam drug interaction

Zalcitabine, it is not concomitant with Abalam because the effect of lamivudine which is present in the drug and Zalcitabine are inhibits each other. If taking getting methadone maintenance therapy, with abacavir 600mg twice daily leads to increase the methadone clearance HLA-B*5701 allele not co administered with abacavir due to anaphylactic reactions occurs Ethanol blocks the ability of the kidney to eliminate the drug abacavir

Abalam contraindication

Abalam tablets are contraindicated in the patients having HLA-B 5701 allele Hypersensitivity reaction to components present in the product Severe hepatic impairment

Abalam precautions

Caution with if patients having; Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B Fat redistribution, myocardial infarction, hepatic impairment


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This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.