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Abalam tablet is indicated for the treatment of patients suffering from HIV type I infection patients.



Abacavir and lamivudine is highly absorbed after oral administration and its bioavailability occurs at 83% and 87% respectively


The drug Abacavir bound to human plasma protein nearly 50%; lamivudine has low plasma protein binding.


Abacavir metabolism occurred by alcohol dehydrogenase and glucuronyl transferase. Lamivudine is metabolized to trans-sulfoxide and biotransformation is catalyzed by sulfotransferases.


The terminal half life of abacavir and lamivudine is 1.54±0.63 hours and 5 to 7 hours respectively. Lamivudine is excreted in human milk


Brand : Abalam
Ingredients : Abacavir & Lamivudine
Strength : Abacavir 600mg & Lamivudine 300mg
Manufactured : Hetero
Package : 30 Tablets

Abalam dosage and administration

The usual dose of Abalam tablet is one tablet of abacavir 600mg nad 300mg Lamivudine, which to be taken orally as a single dose, in combination with other anti-retroviral medicines with or without food.

Abalam side effects

Fatal hypersensitivity reactions Lactic acidosis and severe hepatomegaly with steatosis Exacerbations of hepatitis B Hepatic decompensated in patients co-infected with HIV-I and hepatitis C Immune reconstitution syndrome Fat redistribution Myocardial infraction Some common side effects; Insomnia, depression, headache, fatigue, dizziness, rash, pyrexia, abdominal pain, abnormal pain, anxiety


Abalam drug interaction

Zalcitabine, it is not concomitant with Abalam because the effect of lamivudine which is present in the drug and Zalcitabine are inhibits each other. If taking getting methadone maintenance therapy, with abacavir 600mg twice daily leads to increase the methadone clearance HLA-B*5701 allele not co administered with abacavir due to anaphylactic reactions occurs Ethanol blocks the ability of the kidney to eliminate the drug abacavir

Abalam contraindication

Abalam tablets are contraindicated in the patients having HLA-B 5701 allele Hypersensitivity reaction to components present in the product Severe hepatic impairment

Abalam precautions

Caution with if patients having; Hypersensitivity reactions, lactic acidosis, severe hepatomegaly with steatosis and exacerbations of hepatitis B Fat redistribution, myocardial infarction, hepatic impairment

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