WELCOME TO Million Health Pharmaceuticals

Million-Health-Pharmaceuticals

Mechanism of action


Anastrazole Simultaneously inhibits Aromatase, which an enzyme helped for changing of ambient estrogen to estrone through adrenally growth androstenedione by Aromatase in peripheral tissues Thereby the prevention of Aromatase may leads to reduced in plasma and malignant assembly of estrogen, following to lowering of tumor lump or slow the progress of tumor growth

Pharmacokinetic

Absorption

Rapidly absorption occurs and attains high plasma concentration occurs within 2 hours. Effects of food: food will decrease the rate but not all the extent of anastrazole absorption.

Distribution

The drug anastrazole has human serum protein bound is 40%

Metabolism

The anastrazole metabolism is occurred via N-Dealkylation, hydroxylation and Glucuronidation The metabolites of anastrazole are; Triazole-major circulating metabolite which has poor pharmacological activity A glucoronide conjugate of hydroxyl anastrazole A glucoronide conjugate of anastrazole

Elimination

Nearly 85% of anastrazole reclaimed in feces and urine in Hepatic metabolism: 10% total clearance in Renal metabolism The anastrazole half life is 50 hours


million-pharma-img1

Brand : Anabrez
Ingredients : Anastrazole
Strength : 1mg
Manufactured : Sun Pharmaceuticals
Package : 28 Tablets

dosage management

The Anabrez tablet usual dosage is 1mg should administrated as a single dose by given with or without food In the metastatic breast cancer condition of, Anabrez should be taken until disease improvement Anabrez should be followed for five years in ATAC trials In renal impairment patients or for elderly patients no dose adjustments acquired In mild to moderate hepatic impairment condition no dose adjustment takes place.

Common side effects

Asthenia, pain, back pain, headache, abdominal pain, infection, injury, flu like syndrome, chest pain, neoplasm, cystitis


Cardiovascular

Vasodilatation, hypertension

Digestive

Nausea, constipation, diarrhea, dyspepsia, GI disorders

Blood related effects

Lymph edema, anemia

Metabolism

Peripheral edema, weight gain, hypercholesterolemia

Musculoskeletal

Arthritis, arthralgia, osteoporosis, fracture, bone pain, arthrosis, joint pain, Myalgia

Nervous

Depression, insomnia, dizziness, anxiety, paresthesia

Respiratory

Pharyngitis, cough increased, dyspnea, sinusitis, bronchitis

Skin

Rashes, sweating

Eye

Cataract specified

Urogenital

urinary tract infection, breast pain, breast neoplasm, vulvovaginitis, vaginal hemorrhage, vaginitis ; Leucorrhea



million-pharma-book1

drug interaction

While interaction of tamoxifen with anastrazole leads to reduce the plasma concentration of anastrazole by 27% Not concomitant use with Anabrez tablet which may cause depletion of its pharmacological activity in Estrogen therapy Interaction of Warfarin with anastrazole, it did not alter the anti-coagulant effect Anabrez tablet will change the effect of other drugs, it concluded as CYP-450 prohibition

Precaution

Condition of ischemic cardiovascular action: There is a chance of raising of proportion of ischemic cardiovascular effects while getting Anabrez tablets. Decreased total hip bone density and lumbar spine density when patients receiving Anabrez tablet have chance of getting Cholesterol: The patient receiving tamoxifen may have elevate serum cholesterol level correlated by Anabrez tablets






Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.