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Mechanism of action

Anastrazole Simultaneously inhibits Aromatase, which an enzyme helped for changing of ambient estrogen to estrone through adrenally growth androstenedione by Aromatase in peripheral tissues Thereby the prevention of Aromatase may leads to reduced in plasma and malignant assembly of estrogen, following to lowering of tumor lump or slow the progress of tumor growth



Rapidly absorption occurs and attains high plasma concentration occurs within 2 hours. Effects of food: food will decrease the rate but not all the extent of anastrazole absorption.


The drug anastrazole has human serum protein bound is 40%


The anastrazole metabolism is occurred via N-Dealkylation, hydroxylation and Glucuronidation The metabolites of anastrazole are; Triazole-major circulating metabolite which has poor pharmacological activity A glucoronide conjugate of hydroxyl anastrazole A glucoronide conjugate of anastrazole


Nearly 85% of anastrazole reclaimed in feces and urine in Hepatic metabolism: 10% total clearance in Renal metabolism The anastrazole half life is 50 hours


Brand : Armotraz
Ingredients : Anastrazole
Strength : 1mg
Manufactured : Cipla
Package : 28 Tablets

dosage management

The Armotraz tablet usual dosage is 1mg should administrated as a single dose by given with or without food In the metastatic breast cancer condition of, Armotraz should be taken until disease improvement Armotraz should be followed for five years in ATAC trials In renal impairment patients or for elderly patients no dose adjustments acquired In mild to moderate hepatic impairment condition no dose adjustment takes place.

Common side effects

Asthenia, pain, back pain, headache, abdominal pain, infection, injury, flu like syndrome, chest pain, neoplasm, cystitis


Vasodilatation, hypertension


Nausea, constipation, diarrhea, dyspepsia, GI disorders

Blood related effects

Lymph edema, anemia


Peripheral edema, weight gain, hypercholesterolemia


Arthritis, arthralgia, osteoporosis, fracture, bone pain, arthrosis, joint pain, Myalgia


Depression, insomnia, dizziness, anxiety, paresthesia


Pharyngitis, cough increased, dyspnea, sinusitis, bronchitis


Rashes, sweating


Cataract specified


urinary tract infection, breast pain, breast neoplasm, vulvovaginitis, vaginal hemorrhage, vaginitis ; Leucorrhea


drug interaction

While interaction of tamoxifen with anastrazole leads to reduce the plasma concentration of anastrazole by 27% Not concomitant use with Armotraz tablet which may cause depletion of its pharmacological activity in Estrogen therapy Interaction of Warfarin with anastrazole, it did not alter the anti-coagulant effect Armotraz tablet will change the effect of other drugs, it concluded as CYP-450 prohibition


Condition of ischemic cardiovascular action: There is a chance of raising of proportion of ischemic cardiovascular effects while getting Armotraz tablets. Decreased total hip bone density and lumbar spine density when patients receiving Armotraz tablet have chance of getting Cholesterol: The patient receiving tamoxifen may have elevate serum cholesterol level correlated by Armotraz tablets

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