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Azithral 500mg is indicated for the treatment of certain bacterial infections such as bronchitis, Pneumonia, Sexually transmitted disease (STD) Azithral 500mg is also indicated to prohibit the disseminated Mycobacterium avium complex (MAC) infection Infection of the ears, lungs, sinuses, throat and reproductive organs.

Azithral 500mg belongs to semisynthetic azalide antibiotic and works by linking to the 23S rRNA of the 50S ribosomal subunit of susceptible microorganisms preventing synthesis of bacterial protein and impeding the assembly of the 50S ribosomal subunit.




PHARMACOKINETICS

Absorption

absorbed rapidly from the GI tract. Reduced by food (capsule formulation). bioavailability: Approx 34-52%. Duration of maximumserum concentration: Oral tab: 2-3 hr;

Distribution

Volume of distribution: 31-33 L/kg. The Azithral 500mg tablet based on concentration has Plasma protein binding about 7-51% (oral and IV).

Metabolism

Metabolism occur in Hepatic through demethylation.

Elimination

Through bile (as unchanged drug and inactive metabolites); urine (approx 6% of oral dose). Terminal elimination half-life: 68 hr.




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Brand : Azithral
Ingredients : Azithromycin
Strength : 500mg
Manufactured : Alembic Pharmaceuticals
Packing : 10x6 Tablets

For oral dosage form
In adults for bacterial infections

500 to 2000mg once daily, administer as single dose, this may continue with 250 to 500mg dose once daily for several days

For pharyngitis or tonsillitis

500mg on day 1 taken as single dose followed by 250mg on 2nd day through 5th day

In children for infections (6months age – older)

based on body weight is dose and must be determined by your doctor. 10 to 30mg/kg of body weight once daily, taken as a single dose. Depends on the type of infection, continue with doses of 5 to 10 mg/kg of body weight once daily for several days. Infants < 6 months: discuss with doctor

For pharyngitis or tonsillitis

based on body weight: 12mg/kg of body weight once daily for 5 days < 2yrs children’s: discuss with doctor for dose.

OVERDOSAGE

If dose administer higher than prescribed dose will cause nausea, diarrhea, vomiting. If it occurs, then provide general symptomatic and supportive measures are indicated as needed

Some serious side effects is caused by Azithral 500mg

  • Watery or bloody diarrhae
  • Pain in head associated with chest discomfort and severe vertigo, fainting, fast heartbeats
  • Hepatic problems – upper stomach pain, decreased appetite, dark urine, clay-colored stools, jaundice
  • Serious dermatological reaction – fever, pharyngtitis, blisters in face or tongue, burning of eyes, red or purple skin rashes.

Common side effects of Azithral 500mg as follows

  • Diarrhae
  • Nausea, vomiting, stomach pain
  • Pain in head

If these symptoms occurs call doctor immediately





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DRUG - DRUG INTERACTIONS

Interaction of Azithral 500mg with Nelfinavir will increases azithromycin serum concentrations. Azithral 500mg combination with Warfarin causes Prothrombin times should be carefully monitored while patients gettingcontinues azithromycin and oral anticoagulants Concomitant use with Macrolides leads to Serum concentration of macrolides may increase when combined with Azithromycin

CONTRAINDICATIONS

The patients using Azithral 500mg is contraindicated with hypersensitivity to azithromycin and its components. history of liver discomfort analog to before use of azithromycin

WARNING & PRECAUTIONS

While use of antibacterial agents will cause mild diarrhea to fatal colitis and it alters the normal colon flora results overgrowth of C.difficile. These will produce toxin A and Toxin B leads to development of CDAD and hence increases morbidity and mortality. Before using Azithral 500mg inform the doctor. If an allergic reaction occurs including angioedema, anaphylaxis and dermatologic reactions, the drug should be discontinuing, and convenient treatment must carried out. Consult with doctor for the symptoms arise. If symptoms of abnormal liver function, cholestatic jaundice, liver necrosis have occurred then stop the azithromycin and inform the doctor.


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