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ADME process

Absorption

Rapidly absorbed, time to high plasma protein is 0.8±0.3 hrs

Distribution

human plasma protein bounds of Crixivan is 60%

Metabolism

In hepatic is metabolized

Excretion

< 20% of indinavir is eliminatedin the urine unchanged.

Half life

Half life of Crixivan is 1.8 (±0.4) hours.


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Brand : Crixivan
Ingredients : Indinavir
Strength : 400mg
Manufactured : MSD
Package : 30 Tablets

Dosage and administration

The usual dosage of Crixivan is 800mg administer as two 400mg capsules given orally every 8 hours in combination with other antiretrovirals for the treatment of HIV infections. With Ritonavir then 800mg plus Ritonavir 100mg to 200mg twice a day The patients taking Crixivan must be intervals of 8 hours

Crixivan should administrated without food with water 1 hour before or 2 hours after meal It can be also taken with other liquids such as skim milk,juice,coffee or tea or with a light meal The patients ensure adequate hydration its prescribed adults drinks at least 1.5 liters of liquids during the course of 24 hours

Nephrolithiasis/ urolithiasis

Nephrolithiasis events cumulative frequency increase with increasing exposure of Crixivan hence risk over time remains the same

Hemolytic Anemia

Acute hemolytic anemia involves cases reports in death. Hence discontinuation of Crixivan

Hepatitis

The patient having hepatitis has been treated with Crixivan will leads to hepatic failure and death

Fat redistribution

The mechanism and long term consequence of these events are currently unknown. A causal relationship has not been established.



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Drug interaction

Combination of indinavir with drugs metabolized by CYP3A4 wills increases plasma concentration of the other drugs. Interaction with drugs that induce CYP3A4 activity will increase clearance of indinavir, resulting in reduced plasma concentrations of indinavir

Contraindication

Crixivan contraindicated in Hypersensitivity to any of its components Inhibition of CYP3A4

Pregnancy category is C

There have no adequate and well developed studies in pregnant women. It should be used when potential benefit clarify the possible risk of the fetus


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