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PHARMACOKINETIC

Absorption

Fastly absorbed from the GI tract. Absorption with food is delayed Bioavailability: 80-87% (lamivudine); approx 60-70% (zidovudine). Time to peak plasma concentration: Approx 1 hr.

Distribution

the drug Passes via blood-brain barrier and placenta which enters breast milk and Detected in semen (zidovudine). Volume of distribution: 1.3 L/kg (lamivudine); 1-2.2 L/kg (zidovudine). Human Plasma protein bounding is 36% (lamivudine); 34-38% (zidovudine).

Metabolism

Both the drugs which are metabolized intercellular to form the active triphosphate . Zidovudine go via hepatic metabolism, mainly to the inactive glucuronide.

Excretion

Lamiudine and zidovudine excreted Via urine, (mainly as unchanged drug) Elimination half-life: 5-7 hr (lamivudine); 0.5-3 hr (zidovudine).



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Brand : Duovir
Ingredients : Lamivudine & Zidovudine
Strength : 150mg & 300mg
Manufactured : Cipla
Package : 60 Tablets

SIDE EFFECTS

If any of these side effects occurs while taking Duovir , you should consult with doctor urgently. More common side effects Head pain, Chills, fever, pale skin, sore throat weakness, Less common side effects Stomach ache, nausea, skin rash, vomiting, yellow eyes, coughing, loss of appetite, difficult in sleeping Incident not known: Blurred vision, dry mouth, hair loss, increased (hunger, thirst, urination), chest discomfort, wheezing, myalgia, convulsions.



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DRUG INTERACTION

Duovir given with Emtricitabine may develop cross –resistance. Continue use of Zidovudine with Ribavirin leads to Excerabtion of anemia. Lamivudine and Zalcitabine may prevent intracellularily phosphorylation of one another.

Interaction of Zidovudine with Stavudine and doxorubicin will produce antagonistic effects. Duovir used with interferon alfa in HIV may develop risk of hepatic decompenstion.

PRECAUTION

The women having Obese with hepatomegaly, hepatitis or other risk factors causes liver disease and hepatic steatosis; hepatitis B or C virus co-infection leads risk factors for pancreatitis Patient with poor bone marrow reserve before the treatment. Renal and severe hepatic impairment. Childern Pregnancy.

Monitoring Parameters :Monitor haematological parameters observe for appearance of hardened infections and signs and symptoms of pancreatitis. Continually monitor hepatic function test and for several month following discontinuation of therapy for patients co-infected with hepatitis B virus and HIV.


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This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.