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Efavirenz ( Efamat ) , bioavailabilty is 42% and Peak plasma concentration is 3-5hr.


Efavirenz ( Efamat ) is distributed in CSF, enter into breast milk and protein bound is 99%


Efavirenz ( Efamat ) mainly metabolized inCYP3A4 and CYP2B and isoenzyme to inactive hydroxyl metabolite.


In Efamat excreted via urine(14-34%) and faeces is 16-61% while terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).


Brand : Efamat
Ingredients : Efavirenz
Strength : 600mg
Manufactured : Mylan
Package : 30 Tablets

Side effects

Rash and erythema multiforme CNS effects like dizziness, headache, insomnia, somnolence, abnormal dreams, fatigue, impaired concentration. Nausea, less frequently, vomiting, diarrhoea, hepatitis, depression, anxiety, psychosis, amnesia and ataxia, stupor, abdominal pain, liver failure, pancreatitis, convulsions, gynaecomastia, pruritus, blurred vision.


Efamat with psychoactive drugs leads to additive CNS effects and change plasma warfarin concentrations with warfarin. Interaction with HIV integrase inhibitors (dolutegravir), other HIV NNRTIs ( etravirine), HMG-CoA reductase inhibitors ( simvastatin) reduce plasma concentration Efamat with voriconazole ,plasma concentrations of efavirenz is high and voriconazole is decreased when given continuity. Serious, life-threatening events (e.g. cardiac arrhythmias, respiratory depression) may produce when Efamat given with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil or ergot alkaloids (ergotamine)



Monitor the patients with these problems and inform the healthcare providers: cholesterol and triglycerides. LFTs in patients with history of hepatitis B and/or C.Hepatic Function Use. Convulsions Use with caution in patients with history of seizures.

CNS symptoms Redistribution/accumulation of body fat, including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement.. Liver enzymes in patients with suspected past of hepatitis B or C infection and liver toxicity.

Immune reconstitution syndrome. Lipids Increases in total cholesterol and triglycerides have been checked, Monotherapy Resistant virus may emerge rapidly. Psychiatric symptoms psychiatric disorders may be at greater risk. Some occasional reports of death by suicide, delusions, and psychosis-like behavior. Skin rash Reported in 26% of adults and 46% of children. Over dosage Symptoms Increased CNS symptoms, involuntary muscle contractions.


Concurrent use with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil or ergot alkaloids (ergotamine) causes hypersensitivity, severe hepatic impairment, lactation in patient.

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