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PHARMACOKINETIC

Absorption

Fast absorption from the GI tract, absorption increased with food, peak plasma concentration is approx 2-4hr.

Distribution

Minimal amount distribution enters into CNS, volume of distribution about 0.16-0.66 L/kg. binding of plasma protein is approx 98%.

Metabolism

Empetus is mainly metabolized in liver by CYP3A4 & lesser extent by CYP2D6 isoenzymes.

Elimination

Empetus exceted by both unchanged and metabolite via faeces approx 86% and 3.5% as unchanged drug via urine approx 11%. The terminal elimination half life is 3-5hr.




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Brand : Empetus
Ingredients : Ritonavir
Strength : 100mg
Manufactured : Emcure
Package : 60 Tablets

SIDE EFFECTS

GI effects: abdominal pain, nausea, vomiting, diarrhea, anorexia Common side effects: asthenia, taste disorder, headache, numbness or tingling around the mouth or extremities, anxiety, insomnia, fever, dizziness, malaise, hyperaesthesia, pharyngitis, rash, pruritus, sweating, vasodilatation, wt loss, Allergic reactions : urticaria, bronchospasm, angioedema, mild skin eruptions, immune reconstitution syndrome, lipodystrophy, osteonecrosis, Metabolic abnormalities: hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia. Reduced levels of Hb, K, free and total thyroxine; increased eosinophil, liver enzymes, amylase and uric acid; reduced or increased WBC and neutrophil counts. Major side effects: Pancreatitis, hepatic dysfunction, Stevens-Johnson syndrome. Rarely, anaphyla.



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DRUG INTERACTION

In drug Empetus will Increased plasma conc of certain drugs highly metabolized by CYP3A . Empetus interaction with phenobarbital, carbamazepine, dexamethasone, phenytoin, rifabutin and rifampicn will decrease the plasma concentration. Increased plasma concentration of certain drugs highly metabolized by CYP3A. Empetus interaction with sildenafil leads to serum levels of sildenafil increase.

Serious risk: Avoid contemporaneous admin of oral solution (contains alcohol) with disulfiram / metronidazole. Empetus with simvastatin or lovastatin increased risk of myopathy. Concurrent use Empetus with alfuzosin may lead to serious hypotension.

PRECAUTION

Before taking Empetus , inform your doctors about as follows: Patient with ischaemic heart disease, cardiomyopathy, pre-existing conduction abnormalities or structural heart disease, haemophilia A or B, porphyria, increased triglycerides.

Renal and severe hepatic impairment without decompensation in Childern& Pregnancy. Monitoring Parameters Monitor cholesterol, triglycerides, CBC, LFTs, creatine phosphokinase, uric acid,viral load,CD4 count, serum amylase and lipase, glucose.


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This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.