WELCOME TO Million Health Pharmaceuticals

Million-Health-Pharmaceuticals



PHARMACOKINETIC

Absorption

Efavirenz ( Estiva ) , bioavailabilty is 42% and Peak plasma concentration is 3-5hr.

Distribution

Efavirenz ( Estiva ) is distributed in CSF, enter into breast milk and protein bound is 99%

Metabolism

Efavirenz ( Estiva ) mainly metabolized inCYP3A4 and CYP2B and isoenzyme to inactive hydroxyl metabolite.

Elimination

In Estiva excreted via urine(14-34%) and faeces is 16-61% while terminal half life is 52-76hr(single dose) and 40-55hr (multiple dose).


million-pharma-img1

Brand : Estiva
Ingredients : Efavirenz
Strength : 600mg
Manufactured : Hetero
Package : 30 Tablets

Side effects

Rash and erythema multiforme CNS effects like dizziness, headache, insomnia, somnolence, abnormal dreams, fatigue, impaired concentration. Nausea, less frequently, vomiting, diarrhoea, hepatitis, depression, anxiety, psychosis, amnesia and ataxia, stupor, abdominal pain, liver failure, pancreatitis, convulsions, gynaecomastia, pruritus, blurred vision.

DRUG INTERACTION

Estiva with psychoactive drugs leads to additive CNS effects and change plasma warfarin concentrations with warfarin. Interaction with HIV integrase inhibitors (dolutegravir), other HIV NNRTIs ( etravirine), HMG-CoA reductase inhibitors ( simvastatin) reduce plasma concentration Estiva with voriconazole ,plasma concentrations of efavirenz is high and voriconazole is decreased when given continuity. Serious, life-threatening events (e.g. cardiac arrhythmias, respiratory depression) may produce when Estiva given with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil or ergot alkaloids (ergotamine)



million-pharma-book1

precaution

Monitor the patients with these problems and inform the healthcare providers: cholesterol and triglycerides. LFTs in patients with history of hepatitis B and/or C.Hepatic Function Use. Convulsions Use with caution in patients with history of seizures.

CNS symptoms Redistribution/accumulation of body fat, including central obesity, dorsocervical fat enlargement, peripheral wasting, facial wasting, breast enlargement.. Liver enzymes in patients with suspected past of hepatitis B or C infection and liver toxicity. Immune reconstitution syndrome. Lipids Increases in total cholesterol and triglycerides have been checked, Monotherapy Resistant virus may emerge rapidly.

Psychiatric symptoms psychiatric disorders may be at greater risk. Some occasional reports of death by suicide, delusions, and psychosis-like behavior. Skin rash Reported in 26% of adults and 46% of children. Over dosage Symptoms Increased CNS symptoms, involuntary muscle contractions.

Contraindications

Concurrent use with terfenadine, astemizole, cisapride, midazolam, triazolam, pimozide, bepridil or ergot alkaloids (ergotamine) causes hypersensitivity, severe hepatic impairment, lactation in patient.


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.