WELCOME TO Million Health Pharmaceuticals

Afinitor 5mg tablets are mainly indicated for the treatment of Renal carcinoma. Afinitor 5mg tablets are mainly indicated for the treatment of Breast carcinoma. Afinitor 5mg tablets are mainly indicated for the treatment of Brain carcinoma. Afinitor 5mg is also used in various advanced stage cancer in stomach, intestines or pancreas.

Everolimus is an mTOR prohibitor, joints at high compatibility to FK506 binding protein 12, via producing drug complex which inhibits the specific of mTOR. This inhibition decreases the activity of effectors downstream, that may cause blockage of cell progression from G1 into S phase, subsequently causes cell growth arrest and apoptosis

ADME properties


The high plasma concentration time of Everolimus is 1 to 2 hours. The effect of food with Afinitor 5mg that with heavy meal: Reduction of systemic exposure to Afinitor 5mg 10mg, and the high blood plasma concentration by 54%.


Afinitor 5mg human plasma protein bound with the range of 74%.


The metabolism of Everolimus is occurred in liver, which is a substrate of CYP3A4. The metabolites of Everolimus; Three monohydroxylated metabolite, Two hydrolytic rings opened products, & Phosphatidylcholine conjugate of Everolimus.


The major route of elimination; 5% in urine; the parent compound has been detected in urine or feces. The half-life period of Everolimus is relatively 30 hours


Ingredients : Everolimus
Strength : 5mg
Package : 10 tablets in 1 strips


In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed dosage of Afinitor is 4.5mg/m2 orally as a single dose. In pediatric: The usual pediatric dosage of Afinitor in brain or intracranial tumor is 4.5mg/m2 should be taken orally as a single dose. Afinitor tablets should be administered with or without food.


The over dosage of Everolimus is rarely occur, in case of over dosage patient must be provide with supportive measures. The acute toxicity of Everolimus over dosage should be monitored.


Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes


Increased exposure of skin cancers, patient may protect from UV light

Serious infections

Patients receiving Afinitor 5mg have high risk of acquiring various infections related to bacteria, virus, and fungi. Anti-microbial agents are preferred for the suspected patients.

Hepatic artery thrombosis

In liver transplant patients, Afinitor 5mg therapy should not be recommended.


Renal function should be monitored frequently; caution should be taken while using Afinitor 5mg in renal impaired patients.


This may have occurred in the patients receiving concomitantly Afinitor 5mg with Angiotensin converting enzyme agents


Patient getting Afinitor 5mg with lipid lowering drugs causes increasing in plasma concentration of these drugs causes hyperlipidemia

Interstitial lung disease

Occurred in Afinitor 5mg therapy

Interact with grape juice

Causes increasing blood levels of Everolimus; avoid these concomitants.



Afinitor 5mg interaction with strong inhibitor of CYP3A4, or P-gp, leads to cause decreasing the efflux of Everolimus and increase the plasma concentration of Everolimus. Combination of Afinitor 5mg with verapamil leads to increasing the plasma concentration of Everolimus.

Combination of Afinitor 5mg with Atorvastatin or pravastatin causes rhabdomyolysis, due to increasing concentration of lipid lowering agents. Afinitor 5mg combination with strong CYP3A4 inducers, causes increasing the exposure of Everolimus.

Concomitant use of Afinitor 5mg with cyclosporine causes increasing the AUC level of Everolimus frequently. Afinitor 5mg tablet is interaction with ketoconazole or other CYP3A4 inhibitors causes increasing the plasma concentration and AUC of Everolimus. Concomitant use with erythromycin causes increasing in AUC of Everolimus.


Some anaphylactic reaction occurs, if patients are contraindicated to the components present in the Afinitor 5mg tablets.

Quick Contact

Prescription upload


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.