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Brand : Geftinat
Ingredients : Gefitinib
Strength : 250mg
Manufactured : Natco
Package : 30 Tablets

dosage management

The suggested dosage of Geftinat tablets is 250mg should be administered orally as a single dose. The missed dose should not be taken within 12 hours of next dose.

Administration

Geftinat tablets are administered orally by taking with or without food. If patients are unable to take the tablets through mouth, must disperse tablets in a 4 to 8 ounces of water and mix it well, then drink the liquid immediately or taken via naso-gastric tube.

Dosage adjustment

Stop the Geftinat therapy, if patients have any of the following effects such as; Elevation of ALT & AST levels; Severe ocular disorders like keratitis High skin reactions Acute upraising or aggravation of pulmonary symptoms like cough, fever, dyspnea

Geftinat therapy should be discontinuing forever; in case of

Gastrointestinal perforation Interstitial lung disease Ulcerative keratitis Severe liver damage

Strong CYP3A4 inducers

In concomitant with strong CYP3A4 inducers, the dosage is increased to 500mg; continue the Geftinat therapy with 250mg after cessation of strong CYP3A4 inducers

unwanted effects

The adverse effect of Gefticip tablets

Liver toxicity Gastrointestinal perforation Severe diarrhea Bullous & expoliative skin disorders Ocular disorders Interstitial lung disease

Common side effects

Headache Diarrhea Fatigue Respiratory failure occurs due to pneumonia & pulmonary embolism Mucosal inflammation, tongue ulceration, eye irritation, eyelid Pruritus, edema Elevation of AST, ALT Proteinuria Hemorrhagic cystitis Cutaneous vasculitis Nausea Vomiting Skin reactions Nail disorders Stomatitis Loss of appetite Conjunctivitis Blepharitis Dry eye

Interstitial lung disease

Geftinat therapy is discontinued and immediately examine for ILD in any patients who have acute respiratory problems.

Liver toxicity

Patient getting Geftinat therapy, accidentally elevate AST & ALT levels and increased bilirubin levels leads to cause hepatotoxicity and to rescue from this condition discontinue the therapy.

Gastrointestinal perforation

Stop the Gefitinib therapy permanently.

Persistent diarrhea

Discontinue the Gefitinib therapy

Ocular disorders

Ocular disorders like corneal erosion, aberrant eyelash growth may occur during the therapy of Geftinat . To avoid this problem discontinue the Geftinat therapy.

Skin disorders

Skin disorders like Stevens Johnson’s syndrome, epidermal necrolysis & Erythema multiforme formed during the therapy. Geftinat therapy should be suspended or break off.

Embryo fetal toxicity

Gefitinib produce fetal harm, like fetotoxicity and neonatal death. Not recommended this therapy in pregnant women and use effective contraception methods.



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Drug interaction

Geftinat tablet combined with strong CYP3A4 inducers like phenytoin, rifampicin, or tricyclic depressant may leads to decreasing the plasma concentration of Gefitinib because of increasing the metabolism. To avoid this problem, while concomitant with these drugs, the dosage of Geftinat is increased to 500mg, maintained by 250mg for 7 days after stopping the CYP3A4 inducers. Co administration of Geftinat with strong CYP3A4 inhibitors like itraconazole causes elevating the plasma concentration of Gefitinib due to decreasing in metabolism.

Geftinat combined with gastric regulator, causes depletion of plasma concentration of Gefitinib. Gastric regulators like proton pump inhibitors, H2 receptors antagonist, or antacids. Geftinat tablets are taken 12 hours after the last dose or 12 hours earlier to proton pump inhibitors; Geftinat tablets taken at 6 hours after or earlier to the dose of H2 receptor antagonist or antacids. Geftinat with warfarin leads to produce hemorrhage, to avoid this problem patients monitored frequently for prothrombin time alteration.






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