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Drug interaction

• Adalimumab concomitant use with Gengraf 25mg both increase immunosuppressive effects and cause risk of infection. Avoid the usage of drug
• Gengraf 25mgInteraction with carbamazepine will reduce the level or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid the usage of drug or Use Alternate Drug.
• Acyclovir concomitant use with Gengraf 25mg both increase nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
Gengraf 25mg increases levels of digoxin by lowering renal clearance. Avoid the usage of drug or Use Alternate Drug.
• Azathioprine concomitant use with Gengraf 25mg both increase immunosuppressive effects and cause risk of infection

Contraindication

Gengraf 25mg is a contraindicated :
Hypersensitivity
Breastfeeding
Uses of Rheumatoid Arthritis (RA)/Psoriasis: Abnormal renal function, uncontrolled hypertension, malignancies Concomitant use of PUVA, UVB radiation, coal tar, methotrexate, other immunosuppressants will cause psoriasis






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