Brand : HepBest
Ingredients : Tenofovir Alafenamide
Strength : 25mg
Manufactured : Mylan
Package : 30 tablets
The usual dosage of HepBest tablet is, one tablet containing 25mg of Tenofovir Alafenamide should be taken as a single dose HepBest tablet should be administered with food In creatinine clearance range <15ml/min, HepBest is not recommended In decompensated cirrhosis: HepBest should not be recommended Before initiating the therapy: Patients should examine HIV-1 infection for recommending combination of other anti-retroviral drugs in HIV-1 positive patients.
HepBest -Tenofovir Alafenamide (TAF) TAF is a prodrug of tenofovir (parent drug) At first, TAF is penetrating into hepatic cells because it has lipophilic cell permeable capacity. After enters into the cells, TAF undergoes hydrolysis by using carboxylesterase-1 and to formed as tenofovir. Tenofovir involved in intracellular metabolism, which is phosphorylated into tenofovir triphosphate. Tenofovir triphosphate is considered as an active metabolite which has anti-viral property and integrated into viral DNA by hepatitis B reverse transcriptase enzyme and leads to inhibits viral production thus results as termination of viral chain.
After an oral administration, absorption of HepBest tablet occurs rapidly. The peak plasma time occurs within 0.48 hours The effect of food while taking HepBest tablet is includes as; With high fat meal, the effect of tenofovir Alafenamide is 1.65 HepBest is highly bound to human plasma protein nearly 80% The blood plasma ration is 1.0 Metabolism of tenofovir Alafenamide is occurs with the aid of cathepsin A, carboxylesterase-1 The half life period of tenofovir Alafenamide is 0.51 hour Excretion occurs through urine <1%; feces 31.7%