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After cessation of anti-hepatitis B therapy by using with HepBest tablet, concluded in serious intense aggravation of hepatitis B infection. To avoid this adverse condition in the patients, liver function should be observed frequently.

Exposure of reinforcement of HIV-1 antagonism in HBV/HIV-1 co infected patients In HIV infected patients, combinational therapy is suggested for avoiding this condition in co-infected patients. Check the HIV antibody in all HBV infected patients before starting the therapy.

New commencement and worsening of renal damage Patient with low renal function capability, stop the HepBest tablet therapy immediately and monitored the serum phosphorus, serum creatinine, urine protein, urine glucose and creatinine clearance frequently

Lactic acidosis or serious hepatomegaly with steatosis If this condition occurred in the patients, immediately discontinue the therapy and provide safety measures


Brand : HepBest
Ingredients : Tenofovir Alafenamide
Strength : 25mg
Manufactured : Mylan
Package : 30 tablets

How to take HepBest tablet

The usual dosage of HepBest tablet is, one tablet containing 25mg of Tenofovir Alafenamide should be taken as a single dose HepBest tablet should be administered with food In creatinine clearance range <15ml/min, HepBest is not recommended In decompensated cirrhosis: HepBest should not be recommended Before initiating the therapy: Patients should examine HIV-1 infection for recommending combination of other anti-retroviral drugs in HIV-1 positive patients.

How HepBest works

HepBest -Tenofovir Alafenamide (TAF) TAF is a prodrug of tenofovir (parent drug) At first, TAF is penetrating into hepatic cells because it has lipophilic cell permeable capacity. After enters into the cells, TAF undergoes hydrolysis by using carboxylesterase-1 and to formed as tenofovir. Tenofovir involved in intracellular metabolism, which is phosphorylated into tenofovir triphosphate. Tenofovir triphosphate is considered as an active metabolite which has anti-viral property and integrated into viral DNA by hepatitis B reverse transcriptase enzyme and leads to inhibits viral production thus results as termination of viral chain.

How the body works for HepBest tablets

After an oral administration, absorption of HepBest tablet occurs rapidly. The peak plasma time occurs within 0.48 hours The effect of food while taking HepBest tablet is includes as; With high fat meal, the effect of tenofovir Alafenamide is 1.65 HepBest is highly bound to human plasma protein nearly 80% The blood plasma ration is 1.0 Metabolism of tenofovir Alafenamide is occurs with the aid of cathepsin A, carboxylesterase-1 The half life period of tenofovir Alafenamide is 0.51 hour Excretion occurs through urine <1%; feces 31.7%


Side effects caused during therapy

Important adverse effects; Lactic acidosis or severe hepatomegaly with steatosis Reactivation of hepatitis B viral infection in worsening condition after the therapy Renal damage occurs Some of undesirable effects; Headache Fatigue Cough Nausea Back pain Abdominal pain Reduction in bone mineral density Glycosuria Creatine kinase elevation Amylase lipase elevated

Some drugs may interact with HepBest tablets

HepBest combined with P-gp or BCRP strong inhibitors, results as alteration of absorption of tenofovir Alafenamide P-gp or BCRP inducers, combined with HepBest tablets leads to cause loss of therapeutic effect of HepBest HepBest with P-gp or BCRP moderate inhibitors results as absorption elevation thus causes plasma concentration of tenofovir Alafenamide HepBest tablets combined with anti-convulsants (phenytoin, carbamazepine, or Phenobarbital), anti-mycobacterials (rifampin, rifapentine, or rifabutin) or herbal products (st Johns wort) causes depletion in effect of concentration of HepBest

abdominal pain
abdominal pain
concluded as death
concluded as death
dark urine
dark urine
flu like syndrome
flu like syndrome
loss of apetite
loss of apetite
loss of weight
loss of weight

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