Brand : Ikgdar
Ingredients : Rituximab
Strength : 500mg
Manufactured : Emcure pharmaceuticals
Dosage form : injection
Ikgdar is recommended to administer only through intravenous infusion not by IV push or bolus.BEFORE EACH INFUSION PREMEDICATE
First infusion: initially rate of 50 mg/hr is given , in not showing infusion toxicity, rate raised upto 50 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Successive infusion: 100 mg/hr initiated rate , in not showing infusion toxicity, rate raised upto 100 mg/hr increments at intervals of 30 min and max of 400 mg/hr. Premedication with corticosteroids must be considered, if Ikgdar combination with CHOP chemotherapy is not given.LOW GRADE OR FOLLICULAR NON-HODGKINS LYMPHOMA
Dose is 375 mg/m2 as an IV infusion. Once weeks for 4 or 8 doses administrated for Relapsed treatment Relapsed Retreatment for once weekly for 4 doses administrated. Untreated Previously: given on day 1 of each cycle of chemotherapy, upto 8 doses. In complete or partial response of patient, start with 8 weeks for maintenance following Ikgdar in combination with chemotherapy completed then administer 8weeks for 12 doses as a single agent. Once weekly for 4 dose at intervals of 6 months and max of 16 dose for Non – progression (following CVP chemotherapy completion 6 – 8 cycles) On day 1 each cycle of chemotherapy upto 8 infusions for Diffuse large B- cell NHL.COMPONENT OF ZEVALIN FOR TREATMENT OF NHL
Prior to the administration of Indium-111-(In-111-) Zevalin and Yttrium-90- (Y-90-)Zevalin administer Ikgdar infusion about 250 mg/m2 within 4 hours Before toRituxan and Y-90- Zevalin administrate Rituxan and In-111-Zevalin 7–9 days.
Before starting of FC chemotherapy, dose recommended is 375 mg/m2 followed 500 mg/m2 on day 1 of 2-6 cycles every 28 days.RHEUMATOID ARTHRITIS
Ikgdar is administer with methotrexate combination Ikgdar administrating as two dose of 500mg IV infusion 2 weeks separated. When glucocorticoids administered as methyl prednisolone 500mg IV Subsequent course based on clinical evaluation should administer every 24 weeks, but not early than every 16 weeks.GRANULOMATOSIS POLYANGITIS AND MICROSCOPIC POLYANGITIS
Weekly once for 4 weeks administer Dose of 375 mg/m2 IV infusion While Glucocorticoids combination with methylprednisolone by dose of 1000 mg IV/ day given for 1- 3 days and purse by oral prednisone 1 mg/kg/day are recommended for the treatment of symptoms of serious vasculitis . This drug should intiate within 14 days before or with the starting of Ikgdar 500mg and may continue during and after the 4 week course with treatment of Ikgdar 500mg drug. Safety and not established for subsequent infusion.ADMINISTRATION
Take an Ikgdar amount and diluted to final concentration of 1 mg/ml upto 4 mg/ml as infusion (containing either 0.9% Nacl or 5% dextrose in water). Invert gently the bag and mix the solution. Dispose unused drug left in vial. OVERDOSAGE: If the patients had high dose of Ikgdar then seek immediately to the emergency department or poison control help line. Please consult the doctor for further clarification.
fever and chills (flu lik symptoms)Less common side effects
Weakness; nausea; headache; cough; dyspnae; pharyngitis