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Brand : Imatib
Ingredients : Imatinib
Strength : 400mg
Manufactured : Cipla
Package : 30 Tablets


DOSAGE AND ADMINISTRATION

The usual dose of tablet Imatib 400mg or 600mg as a single dose. Whereas 800mg which is administered as 400mg twice daily. Imatib tablets should be taken with food The recommended dose for following conditions;

Acute lymphoblastic leukemia

In adults, the prescribed dose is 600mg should be taken orally as a single dose.


Myelodysplastic / Myeloproliferative diseases

The usual dose is 400mg PO qDay


Hyperesinophillic syndrome

In this condition, recommended dose is 400mg PO qDay


Chronic myeloid leukemia

Chronic phase: In newly diagnosed patients, the dose of Imatib 400mg tablet is 400mg should be orally taken as a single dose. If the failure of chronic phase of the treatment with interferon alpha therapy; dose is raised to 600mg per day. Quick phase: 600mg PO qDay; dose variation to 400mg PO as twice in a day if there is no serious adverse drug reaction or non leukemia associated neutropenia or thrombocytopenia.


Dermatofibrosarcoma protuberans

Recommended dose is 400mg PO q12hr


Gastrointestinal stromal tumors

The prescribed dose of the tablet Imatib 400mg is 400mg should be taken orally as a twice daily


In pediatric


Chronic myeloid leukemia

<1 year: the safety and efficacy of the drug has not been established ≥1 year: 340mg/m2/day PO; should not be exceed 600mg/day


Acute lymphoblastic leukemia

<1 year: the safety and efficacy of the drug has not been established ≥1 year: 340mg/m2/day PO; should not be exceed 600mg/day



SIDE EFFECTS


General disorders

Weakness, anasarca, chills, malaise


Vascular disorders

Flushing, hemorrhage, hypertension, peripheral coldness, Reynaud’s phenomenon, elevated LDH levels


Skin disorders

Dry skin, alopecia, face edema, Erythema, photosensitivity reactions, nail disorder, purpura, psoriasis, rashes, vascular rash, Stevens Johnson syndrome, acute febrile neutrophillic dermatosis.


Cardiac disorders

Palpitations, pericardial effusion, congestive cardiac failure, tachycardia, pulmonary edema, arrhythmia, atrial fibrillation, cardiac arrest, myocardial infarction, angina pectoris


Gastrointestinal disorders

Abdominal distension, gastro esophageal reflux, dry mouth, gastritis, gastric ulcer, stomatitis, mouth ulcer, eructation, esophagitis, dysphasia, and pancreatitis


Blood and lymphatic system

Pancytopenia, febrile neutropenia, Lymphopenia, esinophillia, thrombocythemia, bone marrow depression, lymphadenopathy, hemolytic anemia, Aplastic anemia


Hepatobiliary

Hepatitis, jaundice, hepatic failure, hepatic necrosis


Immune system

Angioedema


Infection and infestation

Sepsis, herpes simplex, herpes zoster, cellulitis, urinary tract infection, gastroenteritis


Metabolism and nutrition

Weight decreased, loss of appetite, dehydration, gout, hyperuricemia, hypocalcaemia, hyperglycemia, hyponatremia, hyperkelamia, hypomagnesemia


Musculoskeletal

Joint swelling, muscle stiffness, muscular weakness, arthritis


Nerve system

Paresthesia, hypesthesia, syncope, peripheral neuropathy, somnolence, tremor


Renal and urinary disorders

Renal failure, frequency of urine will increased, Hematuria, renal pain


Reproductive system

Breast enlargement, menorrhagia, sexual dysfunction, gynecomastia, erectile dysfunction, menstruation irregular, nipple pain, scrotal edema


Respiratory

Epistaxis, pleural effusion, interstitial pneumonitis, pulmonary fibrosis, pulmonary hypertension, pulmonary hemorrhage


Eye, ear and labyrinth disorders

Conjunctivitis, vision blurred, orbital edema, conjuctival hemorrhage, dry eye, vertigo, tinnitus, eye irritation, eye pain, scleral hemorrhage, retinal hemorrhage, papilla edema, glaucoma



Precautions

in hepatic impairment patients use with caution Avoid concomitant use with strong CYP3A4 inducers Risk of serious ventricular dysfunction (CHF) Bleeding occurs In children Growth retardation occurs

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Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.