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Ingredients : Imatinib
Strength : 100mg
Package : 30 Tablets


The usual dose of tablet Glivec 100mg or 600mg as a single dose. Whereas 800mg which is administered as 400mg twice daily. Glivec tablets should be taken with food The recommended dose for following conditions;

Acute lymphoblastic leukemia

In adults, the prescribed dose is 600mg should be taken orally as a single dose.

Myelodysplastic / Myeloproliferative diseases

The usual dose is 400mg PO qDay

Hyperesinophillic syndrome

In this condition, recommended dose is 400mg PO qDay

Chronic myeloid leukemia

Chronic phase: In newly diagnosed patients, the dose of Glivec 100mg tablet is 400mg should be orally taken as a single dose. If the failure of chronic phase of the treatment with interferon alpha therapy; dose is raised to 600mg per day. Quick phase: 600mg PO qDay; dose variation to 400mg PO as twice in a day if there is no serious adverse drug reaction or non leukemia associated neutropenia or thrombocytopenia.

Dermatofibrosarcoma protuberans

Recommended dose is 400mg PO q12hr

Gastrointestinal stromal tumors

The prescribed dose of the tablet Glivec 100mg is 400mg should be taken orally as a twice daily

In pediatric

Chronic myeloid leukemia

<1 year: the safety and efficacy of the drug has not been established ≥1 year: 340mg/m2/day PO; should not be exceed 600mg/day

Acute lymphoblastic leukemia

<1 year: the safety and efficacy of the drug has not been established ≥1 year: 340mg/m2/day PO; should not be exceed 600mg/day


General disorders

Weakness, anasarca, chills, malaise

Vascular disorders

Flushing, hemorrhage, hypertension, peripheral coldness, Reynaud’s phenomenon, elevated LDH levels

Skin disorders

Dry skin, alopecia, face edema, Erythema, photosensitivity reactions, nail disorder, purpura, psoriasis, rashes, vascular rash, Stevens Johnson syndrome, acute febrile neutrophillic dermatosis.

Cardiac disorders

Palpitations, pericardial effusion, congestive cardiac failure, tachycardia, pulmonary edema, arrhythmia, atrial fibrillation, cardiac arrest, myocardial infarction, angina pectoris

Gastrointestinal disorders

Abdominal distension, gastro esophageal reflux, dry mouth, gastritis, gastric ulcer, stomatitis, mouth ulcer, eructation, esophagitis, dysphasia, and pancreatitis

Blood and lymphatic system

Pancytopenia, febrile neutropenia, Lymphopenia, esinophillia, thrombocythemia, bone marrow depression, lymphadenopathy, hemolytic anemia, Aplastic anemia


Hepatitis, jaundice, hepatic failure, hepatic necrosis

Immune system


Infection and infestation

Sepsis, herpes simplex, herpes zoster, cellulitis, urinary tract infection, gastroenteritis

Metabolism and nutrition

Weight decreased, loss of appetite, dehydration, gout, hyperuricemia, hypocalcaemia, hyperglycemia, hyponatremia, hyperkelamia, hypomagnesemia


Joint swelling, muscle stiffness, muscular weakness, arthritis

Nerve system

Paresthesia, hypesthesia, syncope, peripheral neuropathy, somnolence, tremor

Renal and urinary disorders

Renal failure, frequency of urine will increased, Hematuria, renal pain

Reproductive system

Breast enlargement, menorrhagia, sexual dysfunction, gynecomastia, erectile dysfunction, menstruation irregular, nipple pain, scrotal edema


Epistaxis, pleural effusion, interstitial pneumonitis, pulmonary fibrosis, pulmonary hypertension, pulmonary hemorrhage

Eye, ear and labyrinth disorders

Conjunctivitis, vision blurred, orbital edema, conjuctival hemorrhage, dry eye, vertigo, tinnitus, eye irritation, eye pain, scleral hemorrhage, retinal hemorrhage, papilla edema, glaucoma


in hepatic impairment patients use with caution Avoid concomitant use with strong CYP3A4 inducers Risk of serious ventricular dysfunction (CHF) Bleeding occurs In children Growth retardation occurs

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