WELCOME TO Million Health Pharmaceuticals
Million-Health-Pharmaceuticals

Instgra WORKING AS


Instgra (Dolutegravir) contains antagonistic to viral property against HIV compose I infection. Instgra is classified as an Integrase inhibitor, which can prepared to limit HIV cell improvement by interfering with Integrase definitive to the dynamic site and blockade of strands trade step happened. The viral DNA mix into have cells get stopped This trade method is responsible for HIV cell increment cycle. This prompts impediment of viral activity

ADME properties

Absorption

Maximum plasma concentration time of Dolutegravir is 2 to 3 hours The steady state level reaches within 5 days

Distribution

Dolutegravir is highly bound to human plasma protein at 98.9%

Metabolism

The metabolism of Dolutegravir is occurs through UGT1A1 with some additional contribution from CYP3A.

Elimination

The Dolutegravir half life of is 14 hours. The major route of elimination is urine & as an unchanged form through feces.


million-pharma-img

Brand : Instgra
Ingredients : Dolutegravir
Strength : 50mg
Manufactured : emcure
Package : 30 Tablets

Instgra DOSAGE

In Instgra measurement considers, Creatinine freedom, urine glucose, urine protein esteem ought to be explored. Instgra containing 50mg of Dolutegravir.

Dosage recommendation

The standard measurement of Instgra is one tablet of 50mg to be taken as a solitary dosage as orally. Instgra can be taken with or without food but probably taken with food to enhance exposure. In adults: INSTI (Integrase strand transfer inhibitor)

For new patients or experienced INSTI new or virologically restrained

The recommended dose of Instgra 50mg should be taken as once a day

For new or experienced INSTI new by combining with UGT1A or CYP3A inducers

The recommended dosage of Instgra is 50mg should be given as two times a day

For INSTI already treated with certain INSTI related resistance alternatives

The recommended dosage of Instgra is 50mg should be given as two times a day

In pediatric

The recommended dosage of Instgra for 30 to less than 40kg patients: 35mg should be taken as a once a day For 40kg or greater patients: The prescribed dosage is 50mg once daily.

UNDESIRABLE EFFECTS OF Instgra

For Instgra ; The adverse effects occur in this therapy; Immune reconstitution syndrome Liver toxicity Anaphylactic reactions

The most common side effects like

Insomnia Anxiety Depression Creatine kinase elevation Increase in lipase Neutrophils elevation

SAFETY PRECAUTIONS OF Instgra

Hypersensitivity reaction: This may occur due to contraindication Lack of virological response during drug interaction: The Resistance of Instgra may occur in some patients during concomitant use with some drugs. Immune reconstitution syndrome: Some immune restructuring ailment is occurred during the initial stage of anti-retro viral therapy Liver damage: Elevation of AST & ALT levels causing liver damage; to avoid this problem monitor the patients with frequent liver function test.



million-pharma-book1

Instgra INTERACTS WITH SOME OTHER DRUGS

Instgra combines with drugs excreted through OCT2 or MATE1 (dofetilide or metformin), causes elevation of plasma concentration of these drugs. Instgra combined with etravirine causes decrease in plasma concentration of Dolutegravir.

Instgra concurrently used with anti-mycobacterials, anti-convulsants or herbal products causes depletion in plasma concentration of Dolutegravir. Dolutegravir is a substrate of UGT1A3, UGT1A9, BCRP & P-gp transporters. Instgra combined with the drug which prohibits these enzymes or transporters cause, increasing the plasma concentration of Dolutegravir.

Instgra tablets is concomitant use with non-nucleoside reverse transcriptase inhibitors; causing depletion of effect of concentration of Instgra . If Instgra tablets is combines with protease inhibitor causes decreasing in plasma concentration of Dolutegravir.

Instgra CONTRAINDICATED TO

In Instgra causes some hypersensitivity reaction to the patients who are contraindicated to the component of Instgra tablet.


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.