Sofosbuvir with ledipasvir

Ledihep

Indication:

Ledihep is a prescription medicine contains ledipasvir 90mg and sofosbuvir 400mg used to treat chronic Hepatitis C infection for the genotypes of 1,4,5 or 6 with or without cirrhosis that prevent hepatitis C virus (HCV) from multiplying in human body. Ledihep also used with Ribavirin for the patients with advanced decompensated cirrhosis for Genotype 1 or with Genotype 1 or 4 with or without compensated cirrhosis patients who had liver transplantation.

Consult with your doctor before taking the medicine Ledihep, your liver problems and other diseases Hepatitis B history Liver transplant Kidney disease (suppose if you are on Dialysis) under the treatment of heart rhythm problem cardiocare medicines HIV or AIDS treatments Ledihep along with Ribavirin should not use if you have the following , severe kidney disease; a hemoglobin blood cell disorder such as sickle-cell anemia or thalassemia; or if you are pregnant, or if you are a man and your sexual partner is pregnant. if you are pregnant or plan to become pregnant ,inform to your doctor before taking Ledihep Ledihep sometimes used with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before taking ribavirin and every month during your treatment. Suppose you are a woman, avoid or do not take ribavirin if you are pregnant. If you are a man, avoid or do not take ribavirin if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. Use at least 2 effective forms of birth control to prevent pregnancy while either sexual partner is taking ribavirin. Keep using 2 forms of birth control for at least 6 months after treatment ends. Tell your doctor immediatly right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Suppose if you are breast feeding mother to a baby ,immediatly inform to your doctor, because ribavirin passes thru the breast feeding affect the child Ledihep approved for the age morethan 12 years Take Ledihep exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You can take Ledihep with or without food. Take Ledihep eachday at sametime until the treatment get complete. if you've never taken Ledihep, your doctor may prescribe an 12-week course of Ledihep regardless of whether you have irreversible liver damage (cirrhosis).


Brand name:Ledihep

Active Ingeridents: Ledipasvir & Sofosbuvir

Company Name: Zydus

Package:28 tablets/bottle

Strength : Ledipasvir 90mg & Sofosbuvir 400mg

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledihep Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Store:

Ledihep (ledipasvir & Sofosbuvir) room temperature away from moisture and heat

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

  • fatigue
  • nausea
  • headache
  • diarrhea
  • insomnia

Precaution:

  • Tell your doctor or dentist that you take Ledihep (ledipasvir and sofosbuvir) before you receive any medical or dental care, emergency care, or surgery.
  • Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Warning

Ledihep (ledipasvir & Sofosbuvir) is a prescription drug and should be used under proper medical guidance and advice. The information provided here is for general educational purposes only and does not constitute medical or pharmaceutical advice which should be sought from qualified medical and pharmaceutical advisers.