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In adult, Lenvatinib 10mg is indicated for the treatment of metastatic, progressive, radioactive Differentiated Thyroid cancer. Lenvatinib 10mg in combination with everolimus is indicated in patients for the treatment of advance Renal Cell Carcinoma following treatment before anti-angiogenic therapy.

Lenvatinib 10mg is also indicated for the first line treatment in patients suffering with unresectable hepatocellular carcinoma.

Lenvatinib is a tyrosine kinase inhibitor which has shown mainly anti-angiogenic properties, and direct prevention of malignant developed was also observedinside the models.

Lenvatinib which selectively prevents the kinase functions of vascular endothelial growth factor receptors 1(FLT1), 2 (KDR), 3 (FLT4), Although not been studied directly with Lenvatinib, the mechanism of action (MOA) for High blood pressure is hypothesizing to be resolve by the prevention of VEGFR2 in vascular endothelial cells. Same as the, the action for proteinuria is hypothesizing to be interfere with down regulation of VEGFR1 and VEGFR2 in the cell of bowman’s capsules of the glomerulus.

ADME properties Lenvatinib 10mg


Time to high plasma concentration is 1-4 hours post dose. Effect with food is low to the extent Lenvatinib of absorption.


Bounding of Human plasma proteins is 98% to 99%.


Lenvatinib 10mg is primarily metabolized in CYP3A. Lenvatinib 10mg metabolic pathway is identified as enzymatic and non-enzymatic processes.


Eliminated via 64% feces and 25% urine


Ingredients : Lenvatinib
Strength : 10mg
Manufactured : Eisai Co. Ltd
Package : 20 Capsules

Dosage and administration of Lenvatinib 10mg

The usual dose of Lenvatinib for the adult patients is 24mg and administer has two 10mg capsules and one 4mg capsule given orally, once daily taken with or without food. The Lenvatinib tablet should continue until disease progression or until unacceptable toxicity occurs. Take Lenvatinib tablet at the same time. Patients with severe renal or hepatic impairment the dose is 14mg administer once daily orally.


Lenvatinib is not expected to be dialyzable because of maximum plasma protein binding and if the dose getting of Lenvatinib 120mg orally then causes death due to multiorgan dysfunction occurred in the patients.

Common side effects

Tiredness Peeling of skin on palms and sole of the feet Constipation Loss of appetite Weight loss Joint and muscle pain Insomnia

Serious side effects

Shortness of breath Chest pain Pain in arm, back, neck or jaw Seizures Black, tarry or bloody stools Heavy menstrual bleeding Coughing up blood Yellowing of the skin or eyes


Lenvatinib 10mg combination with Carboplatin, paclitaxel has no specific pharmacokinetics impact Interaction with CYP3A, Pglycoprotein (P-gp) inhibitors and inducers has no dose adjustment for Lenvatinib 10mg.



Blood pressure may increase while treatment with Lenvatinib 10mg . Your doctor will preferably check your blood pressure during your treatment. Inform the doctor if you are allergic to Lenvatinib 10mg , any other regimens, or any of the ingredients in Lenvatinib 10mg capsules.

Other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may to change the doses of your drugs or guide carefully for adverse reaction.

Inform doctor if you have or had seizures, hypertension, a stroke, a heart attack, , especially those due to blood clots, a fistula, a tear in the wall of your GIT, QT interval prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), low levels of Ca,K or Mg in your blood, bleeding problems, or cardiac, renal, or hepatic disease.

Take into the knowledge that Lenvatinib 10mg may reduce the fertility in men and women. It not means that you or your partner cannot become pregnant. Inform doctor before if you are pregnant or plan to become pregnant. After becoming pregnant, you should use birth control while treatment with Lenvatinib 10mg and for at least 2 weeks after your treatment, become pregnant during Lenvatinib therapy, call your doctor immediately. Lenvatinib 10mg may harm the fetus. Inform the doctor if you are breastfeeding or plan to breastfeed. Avoid breastfeed during Lenvatinib 10mg treatment.

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