WELCOME TO Million Health Pharmaceuticals

Million-Health-Pharmaceuticals

Naivex Tafero EM pharmacological category


Both are anti-retro viral medication Naivex : Integrase strand transfer inhibitor (Integrase is an enzyme responsible for transferring HIV genetic material into human chromosome causes production) Tafero EM : Reverse transcriptase inhibitor (RT is also an enzyme essential for viral production)

Tafero EM undergoes ADME properties

Absorption

Greatest plasma fixation time of Dolutegravir is 2 to 3 hours The consistent state level reaches inside 5 days

Distribution

Dolutegravir is very bound to human plasma protein at 98.9%

Metabolism

The digestion of Dolutegravir is happens through UGT1A1 with some extra commitment from CYP3A.

Elimination

The terminal half existence of Dolutegravir is 14 hours. The significant course of disposal is urine and as an unaltered frame through feces.



million-pharma-img


Naivex undergoes ADME properties

Most extreme plasma fixation time of Emtricitabine is comes to inside 3 hours; TAF is 60 minutes The inception of protein restricting information for TAF and Emtricitabine is happens ex-vivo and in vitro individually. The blood plasma proportion of TAF and Emtricitabine is 1.0 and 0.6 separately TAF and Emtricitabine limits to human plasma protein at 80% and <4% separately

The digestion of TAF and Emtricitabine; TAF: Metabolized by cathepsin A, carboxyl esterase 1 or CYP3A at negligible level. Emtricitabine digestion is happened by means of biotransformation. The fundamental discharge of TAF and Emtricitabine are happens through; >80% of medication get used and through renally separately. The terminal half existence of; TAF: 0.51 hour Emtricitabine: 10 hours Emtricitabine: 70% of metabolite discharged through urine; 13.7% by means of excrement TAF: <1% in urine; 31.7% feces.

dosing consideration

In Tafero EM , going before to begin the treatment, calm ought to be broke down by and large whether hepatitis B contamination sickness is suspected in the particular patient or not. Patients creatinine clearance, urine protein, urine glucose should be monitored periodically.

Naivex Tafero EM contents; Naivex : Comprising of 50mg of Dolutegravir Tafero EM : Comprising of 25mg of Tenofovir Alafenamide; 200mg of Emtricitabine

Brand : Naivex Tafero EM
Ingredients : Dolutegravir; Tenofovir Alafenamide & Emtricitabine
Strength : 50mg 25mg & 200mg
Manufactured : Hetero
Package : 30 Tablets

The dosage recommendation of Naivex & Tafero EM

The usual prescribed dose of both the product is one tablet should be administered orally as a single dose. Naivex and Tafero EM should be taken with or without food. Naivex and Tafero EM should be able to take in adults patients and pediatric having body weight of at least 35kg Creatinine clearance is important for recommending the dosage of Tafero EM . If patient have CrCl range is greater or equal to 30ml/min it is considered as severe renal impairment condition, Tafero EM should not be suggested.

Recommendation for Naivex

In adults: INSTI (Integrase strand transfer inhibitor) For new patients or experienced INSTI new or virologically restrained: The prescribed dose of Naivex in this condition is 50mg should be taken as once a day For new or experienced INSTI new by combining with UGT1A or CYP3A inducers: The prescribed dose of Naivex is 50mg should be given as two times a day For INSTI already treated with certain INSTI related resistance alternatives: The prescribed dose of Naivex is 50mg should be given as two times a day

In pediatric

The suggested dosage of Naivex for 30 to less than 40kg patients: 35mg should be taken as a once a day orally For 40kg or greater patients: The prescribed dosage is 50mg once daily should be administered orally.

Naivex Tafero EM works as

Naivex

Naivex (Dolutegravir) contains opposing to viral property against HIV make I contamination. Naivex is named an Integrase inhibitor, which can arranged to confine HIV cell change by meddling with Integrase complete to the dynamic site and barricade of strands exchange step happened. The viral DNA blend into have cells get ceased This exchange strategy is in charge of HIV cell increase cycle. This prompts obstacle of viral movement

Tafero EM

Tafero EM has two areas which exhibits debilitating to retroviral movement, against HIV-1 infection. TAF and Emtricitabine TAF: TAF is a prodrug, change over to tenofovir by hydrolysis. TAF has cell defenselessness property which will strike into the cells and changed over into tenofovir through hydrolysis utilizing cathepsin A as an impetus. Tenofovir again under goes phosphorylation to pass on tenofovir diphosphate, a working metabolite of tenofovir by cell kinase. Tenofovir diphosphate, shows it's undermining to retroviral action against HIV by embeddings into viral DNA with the assistance of HIV turn transcriptase and limits HIV replication and causes chain impediment Emtricitabine is besides changed over into Emtricitabine 5 triphosphate, this metabolite is secured with HIV mimicking confinement. Emtricitabine 5' triphosphate is doing battling with normal substrate deoxycytidine 5' triphosphate and introduced into viral DNA and causes chain end

Naivex Tafero EM side effects

Tafero EM

Acute aggravation of hepatitis B Lactic acidosis Worsening of hepatomegaly with steatosis Immune restructured syndrome Renal impairment

Common side effects

Hepatitis Myositis Some psychiatric problems Renal impairment Pruritus Elevation of AST & ALT Abnormal dreams Vertigo Gastrointestinal disorders Increasing bilirubin Dizziness Headache, nausea, diarrhea Rash Fatigue

Naivex

The adverse effects occur in this therapy; Anaphylactic reactions Immune reconstitution syndrome Liver toxicity

The most common side effects like

Insomnia Neutrophils elevation Anxiety Depression Creatine kinase elevation Increase in lipase

Naivex Tafero EM interaction occurs with some drugs

Naivex

Naivex joins with drugs discharged through OCT2 or MATE1 (dofetilide or metformin), causes height of plasma convergence of these medications. Naivex joined with etravirine causes diminish in plasma distribution of Dolutegravir. Naivex simultaneously utilized with hostile to mycobacterials, against convulsants or home grown items causes exhaustion in plasma distribution of Dolutegravir. Dolutegravir is a substrate of UGT1A3, UGT1A9, BCRP and P-gp transporters. Naivex joined with the medication which forbids these chemicals or transporters cause, expanding the plasma centralization of Dolutegravir. Naivex tablets is attendant use with non-nucleoside turn around transcriptase inhibitors; causing consumption of impact of convergence of Naivex . On the off chance that Naivex tablets are consolidates with protease inhibitor causes diminishing in plasma distribution of Dolutegravir.

Tafero EM

Tafero EM is joined with drugs repressing BCRP or P-gp transporters, prompts cause change in assimilation in TAF, brings about loss of helpful movement of Tafero EM tablet. With hostile to convulsants, against mycobacterials, herbal products like st. Johns wort causes diminishing the plasma convergence of TAF prompts bringing down the viability of Tafero EM tablet. Tafero EM is significantly wiped out through renally; medicate which influence the renal capacity joined with Tafero EM tablet causes expanding the grouping of TAF and Emtricitabine prompts lift unfriendly impacts Maintain a strategic distance from associative utilization of Tafero EM with tipranavir prompts because diminishing the impact of grouping of TAF.



Naivex Tafero EM safety measures

million-pharma-book1

Tafero EM

The most genuine impacts may happen; Exacerbation of hepatitis B in HBV/HIV co tainted patients: Before beginning the treatment patients ought to be researched appropriately, if HBV disease is as of now present or not. Lactic acidosis or hepatomegaly with steatosis: Stop the treatment with Tafero EM Insusceptible rebuilding disorder (Immune reconstitution): Some Immune reconstituting disorder is happened amid the underlying phase of hostile to retro viral treatment. Out breaking or exacerbating of renal harm: Avoid simultaneous utilization of medications decreasing renal capacity with Tafero EM and screen the renal capacities every now and again amid the treatment.

Naivex

An anaphylactic reaction: This may happen because of contraindication Absence of virological reaction amid tranquilizes communication: The Resistance of Naivex may happen in a few patients amid accompanying use with a few medications. Immune reconstitution disorder: Some safe rebuilding disease is happened amid the underlying phase of hostile to retro viral treatment Liver harm: Elevation of AST and ALT levels causing liver harm; to keep away from this issue screen the patients with visit liver capacity test.


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.