WELCOME TO Million Health Pharmaceuticals

Million-Health-Pharmaceuticals

PHARMACOKINETIC

Absorption

Bioavailabilty of Nevimune in human is 93±9% for 50mg tablet and 91 ± 8% for oral solution and in rate is 89.7%. peak plasma concentration is 2 ± 0.4 mcg/ml attained by 4 hours.

Distribution

Plasma protein binding is 60%

Metabolism

Nevimune extensively biotransformed via cytochrome P450 and metabolished to several hydroxylated metabolites

Excretion

Excreted via urine 81.8 ± 11.1% and feces in 10.1 ± 1.5% Total radioactive in urine is 80% was made up of gluvuronide conjugation. Half life is 45 hours


million-pharma-img2

Brand : Nevimune
Ingredients : Nevirapine
Strength : 200mg
Manufactured : Cipla
Package : 60 Tablets

Drug interaction

Drugs extensively metabolised by CYP3A or CYP2B6 while interacting with. Efavirenz, atazanavir/ritonavir, fosamprenavir w/o ritonavir. Ketoconazole, fluconazole, itraconazole, warfarin, rifampicin, methadone, Nevimune interaction with Oral contraceptives, clarithromycin, St. John's wort. Adefovir, boceprevir, entecavir, interferons (pegylated interferons alfa 2a & alfa 2b), ribavirin, telaprevir, telbivudine; elvitegravir/cobicistat; delavirdine, etravirine, rilpivirine; emtricitabine, abacavir.

Contraindication

Patients are contraindicated with moderate or severe (Child-Pugh Class B or C, respectively) hepatic impairment Forindicatedas part of occupational and non-occupational post-exposure prophylaxis (PEP) drugs.





million-pharma-book1

Precaution

Hepatotoxicity and hepatic impairment
Serious life-threatening in patient, and in some cases fatal hepatotoxicity, involving fulminant and cholestatic hepatitis, hepatic necrosis and hepatic failure, have been reported in patients treated with Nevimune .

Skin reaction
Serious and life-threatening skin reactions, involves fatal cases, have been reported in patients taking Nevimune .

Drug interactions
Concomitant use of Nevimunewith efavirenz is not recommended as this combination has been associated with an increase in adverse reactions and no improvement in efficacy. Resistance

Immune reconstituents
Immune reconstitution syndrome has been resulted in patients reacted with combination antiretroviral therapy, including Nevimune . During the initial phase of combination antiretroviral treatment, patients whose immune system behave may grow an inflammatory response to indolent or residual opportunistic infections (such as Mycobacterium avium infection, tuberculosis, cytomegalovirus or Pneumocystis jiroveci pneumonia), which may necessitate further evaluation and treatment.

Fat redistribution
Redistribution/aggregation of body fat involves central obesity,buffalo hump (dorsocervical fat enlargement), peripheral wasting, facial wasting, breast enlargement, and “cushingoid appearance” have been observed in patients receiving antiretroviral therapy


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.