Nevir tablet USP is indicated in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV-1) infection in adults and pediatric patients 15 days and older
The dose recommended for adult
The recommended dose for Nevir is one 200 mg tablet daily for the first 14 days, followed by one 200 mg tablet twice daily, in combination with other antiretroviral agents.
The 14-day lead-in period with Nevir200 mg daily dosing must be strictly followed as the lead-in period has been observed to decrease the incidence of rash. If rash continueapart from the 14-day lead-in period, do not dose expand to 200 mg twice daily.
The 200 mg once-daily dosing medication should not be continued above 28 days, at which point, an alternative drugs should be desired. For combination administered antiretroviral therapy,
Theusual dosage and monitoring should be followed.
For pediatrics
The usual oral dose for pediatric patients 15 days and older :
150 mg/m 2 given once daily for period of 14 days followed by 150 mg/m 2 administered twice daily thereafter.
The entiredose for daily should not exceed 400 mg for any patient.
Nevir is belongs to a non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. Nevirlinks directly to reverse transcriptase (RT) and stops the RNA- dependent and DNA-dependent DNA polymerase activities by making a division of the enzyme's catalytic site. The action of Nevirhave not finished with template or nucleoside triphosphates. HIV-2 RT and eukaryotic DNA polymerases such as human DNA polymerases α, ß, γ, or δ are not prohibit by nevirapine.
Bioavailabilty of Nevir in human is 93±9% for 50mg tablet and 91 ± 8% for oral solution and in rate is 89.7%. peak plasma concentration is 2 ± 0.4 mcg/ml attained by 4 hours.
Plasma protein binding is 60%
Nevir extensively biotransformed via cytochrome P450 and metabolished to several hydroxylated metabolites
Excreted via urine 81.8 ± 11.1% and feces in 10.1 ± 1.5% Total radioactive in urine is 80% was made up of gluvuronide conjugation. Half life is 45 hours
Brand : Nevir
Ingredients : Nevirapine
Strength : 200mg
Manufactured : Emcure
Package : 60 Tablets
Drugs extensively metabolised by CYP3A or CYP2B6 while interacting with. Efavirenz, atazanavir/ritonavir, fosamprenavir w/o ritonavir. Ketoconazole, fluconazole, itraconazole, warfarin, rifampicin, methadone, Nevir interaction with Oral contraceptives, clarithromycin, St. John's wort. Adefovir, boceprevir, entecavir, interferons (pegylated interferons alfa 2a & alfa 2b), ribavirin, telaprevir, telbivudine; elvitegravir/cobicistat; delavirdine, etravirine, rilpivirine; emtricitabine, abacavir.
Patients are contraindicated with moderate or severe (Child-Pugh Class B or C, respectively) hepatic impairment Forindicatedas part of occupational and non-occupational post-exposure prophylaxis (PEP) drugs.
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