Tablet Pirfenex is anti-fibrotic agent involved in the treatment of idiopathic pulmonary fibrosis (lung disease).
Pirfenex Tablet is primarily indicated for the treatment of Idiopathic Pulmonary Fibrosis (IPF) condition.
Pirfenex , the pharmacological action of the drug is not completely established. Tablet Pirfenex is apersuasive anti-fibrotic and anti-inflammatory agent. Anti-fibrotic activity of Pirfenex is primarily taken into consideration. Pirfenex , number of cell-basedtreatment takes place. It causes to reduce fibroblast replication, inhibits TGF-β accelerated collagen production, and reduce the synthesis of fibro genic mediators like TGF-β (transforming growth factor). Pirfenex has activity to lower the production of inflammatory mediators like TNF-α (tumor necrosis factor) and IL-1β (interleukin 1 beta).
The absorption of drug Pirfenidone is different among the condition of the patient. In healthy persons, absorption occurs within 20-60mins. If tablet Pirfenex taken with food somewhat reduce the absorption. But in older adults, tablet Pirfenex is Combination with food willincrease tolerability.
Tablet Pirfenex has bounding to plasma proteins, mainly with serum albumin. Administration within 1-3 hours, protein binding was 54-62%.
In Liver, drug Pirfenex is metabolized. Approximately 48% of drug is metabolized via CYP1A2 with other CYP isoenzymes. The main metabolite is 5-carboxy-pirfenidone.
The elimination half-life is around 2.4 hours. About 80% of the metabolites cleared in urine within 24 hours. Tablet Pirfenex after administration, excreted as major metabolite 5-carboxy-pirfenidone (95%), with less than 1% of drug Pirfenidone excreted consistent as well in the urine.
Brand : Pirfenex
Ingredients : Pirfenidone
Strength : 200mg
Manufactured : Cipla
Dosage form : film coated tablet
The prescribed dose of tablet Pirfenex in adolescent is 200mg for three times a day (TID), 600mg/day. Based upon the serious of the condition (IPF), dosage may adjust up to 1800mg/day. Dosage of the tablet Pirfenex depending up on symptom. Initially patient starts with 200mg TID, after 2 weeks, dose may gradually increase to 600mg at a time (1800mg/day).
Dose adjustment and other consideration for safe usePatient, during treatment with tablet Pirfenex may affected by gastrointestinal side effects, so patient advice by taking tablet Pirfenex with food. If a symptom sustain means, dose may decrease to 1-2 tablets given for 2-3 times a day with food.
Photo sensitive reactionsIf rashes endure for 7 days, tablet Pirfenex should be discontinued for 14 days. It is continued by the guidance of health care providers.
Most common side effects caused by Pirfenex include:
• Photosensitivity reactions like rashes
• Decreased appetite
• Stomach pain
• Nausea
• Increased AST and ALT levels
• Fatigue
• Diarrhea
• Dyspepsia
upper respiratory tract infections, UT, Agranulocytosis, Angioedema, Anorexia, weight decreased, loss of appetite, Insomnia, Headache, dizziness, somnolence, dysgeusia, lethargy, Hot flush, Dyspnea, cough, Gastro esophageal reflux, vomiting, constipation, gastritis. ALT, AST increased, serum albumin increased.
Pirfenex tablets should be use with caution; In the conditions like; While patient taking tablet Pirfenex , they may cause to, Increase of liver enzymes Photosensitivity and rash Gastro intestinal disorder Consumption of grapefruit juice: cause inhibit CYP1A2. It should be avoided during the treatment.
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