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The absorption of drug Pirfenidone is different among the condition of the patient. In healthy persons, absorption occurs within 20-60mins. If tablet Pirfenex taken with food somewhat reduce the absorption. But in older adults, tablet Pirfenex is Combination with food willincrease tolerability.


Tablet Pirfenex has bounding to plasma proteins, mainly with serum albumin. Administration within 1-3 hours, protein binding was 54-62%.


In Liver, drug Pirfenex is metabolized. Approximately 48% of drug is metabolized via CYP1A2 with other CYP isoenzymes. The main metabolite is 5-carboxy-pirfenidone.


The elimination half-life is around 2.4 hours. About 80% of the metabolites cleared in urine within 24 hours. Tablet Pirfenex after administration, excreted as major metabolite 5-carboxy-pirfenidone (95%), with less than 1% of drug Pirfenidone excreted consistent as well in the urine.


Brand : Pirfenex
Ingredients : Pirfenidone
Strength : 200mg
Manufactured : Cipla
Dosage form : film coated tablet

Dosage and administration

The prescribed dose of tablet Pirfenex in adolescent is 200mg for three times a day (TID), 600mg/day. Based upon the serious of the condition (IPF), dosage may adjust up to 1800mg/day. Dosage of the tablet Pirfenex depending up on symptom. Initially patient starts with 200mg TID, after 2 weeks, dose may gradually increase to 600mg at a time (1800mg/day).

Dose adjustment and other consideration for safe use
Gastro intestinal events

Patient, during treatment with tablet Pirfenex may affected by gastrointestinal side effects, so patient advice by taking tablet Pirfenex with food. If a symptom sustain means, dose may decrease to 1-2 tablets given for 2-3 times a day with food.

Photo sensitive reactions

If rashes endure for 7 days, tablet Pirfenex should be discontinued for 14 days. It is continued by the guidance of health care providers.

Side effects of tablet Pirfenex

Most common side effects caused by Pirfenex include:
• Photosensitivity reactions like rashes
• Decreased appetite
• Stomach pain
• Nausea
• Increased AST and ALT levels
• Fatigue
• Diarrhea
• Dyspepsia

Adverse reactions

upper respiratory tract infections, UT, Agranulocytosis, Angioedema, Anorexia, weight decreased, loss of appetite, Insomnia, Headache, dizziness, somnolence, dysgeusia, lethargy, Hot flush, Dyspnea, cough, Gastro esophageal reflux, vomiting, constipation, gastritis. ALT, AST increased, serum albumin increased.

Precaution and warning

Pirfenex tablets should be use with caution; In the conditions like; While patient taking tablet Pirfenex , they may cause to, Increase of liver enzymes Photosensitivity and rash Gastro intestinal disorder Consumption of grapefruit juice: cause inhibit CYP1A2. It should be avoided during the treatment.


Drug interaction

Tablet Pirfenex has some of drug interactions, which is concillate by cytochrome enzyme Tablet Pirfenex is metabolized through the CYP1A2 enzyme pathway. The various drug which inhibits this cytochrome enzyme leads to accumulation of toxicity of Pirfenidone.

Some of the CYP1A2 inhibitors medicines like Fluvoxamine, ciprofloxacin, amiodarone etc. These are strong inhibitors like paroxetine, fluconazole, and chloramphenicol.

Omeprazole is a CYP1A2 inducers is used cautiously with tablet Pirfenex , might have chance to reduce the plasma level of the drug Pirfenidone.

Cigarette smoking: Smoking during the treatment with tablet Pirfenex causes increased clearance of Pirfenidone.


Pirfenex tablets are contraindicated to the patient having hypersensitivity to active ingredient Pirfenidone.

Some Other conditions also contraindicated; Angioedema with Pirfenidone Adjuvant use of Fluoxamine Severe hepatic and renal impairment

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