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Pomalid 4mg WORKS AS


Pomalid has three primary pharmacological activities against cancer cells. Pomalidomide includes in the way cancer proliferation and provoke the apoptosis of cancer cells. Pomalidomide enhance the T cell & natural killer cells interceding immunity & inhibits the formation of pro inflammatory cytokines from monocytes. Pomalidomide forbid the new cell formation. The binding of Pomalidomide to active site of targeted cell causes inhibition of ubiquitin ligase action.

ADME properties

The time to high serum concentration of Pomalidomide is reaches between 2 to 3 hours. It should be administered with or without food. Hence No effect of food should be produced; Volume of distribution of Pomalidomide is between 62 & 138L in steady state.

The Pomalidomide distribution by 67% of serum level at after 4 hours of drug intake. human plasma protein by bounding range of 12% & 44%. Hepatically mediated through CYP1A2, CYP3A4 is Pomalidomide is metabolized.

Pomalidomide clearance value is 7 to 10L/hr. Doses are excreted via urine 73% & feces 15% respectively. Doses are excreted as an unchanged form via urine 2% & feces 8%. Pomalidomide half life period is 9.5 hours.


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Brand : Pomalid
Ingredients : Pomalidomide
Strength : 4mg
Manufactured : Natco
Package : 21 Tablets

During multiple myeloma malignancies

The dosage recommendation of Pomalid 4mg is 4mg should be administered as a single dose for 1 to 21 days of successive 28 day cycles. Pomalid is combined with dexamethasone with low dose. Administrate Dexamethasone on day 1, 8, 15 & 22 of each 28 day cycle. The prescribed dose of dexamethasone is 40mg should be administered the patient having weight about ≤ 75kg. The prescribed dose of dexamethasone is 20mg given for patient’s weight Greater than 75kg

Dosage alteration during hematological toxicities Neutropenia

ANC <500/mcL: Pomalid treatment should be postponed and check the CBC weekly. ANC ≥ 500/mcL: Pomalid therapy should be continued by 3mg/day For each successive drop <500/mcL: Pomalid 4mg should be postponed. ANC ≥ 500/mcL: Continue the Pomalid therapy with 1mg/day.

Thrombocytopenia

Platelets count <25000/mcL: Pomalid therapy should be postponed and check CBC Platelets count ≥50000/mcL: 3mg of Pomalid should be taken daily

With strong CYP1A2

Pomalid combined with CYP1A2 substrates causes increasing the plasma concentration of Pomalidomide and leads to elevate the risk of Pomalidomide.

In renal damaged patients

In severe renal impaired patients, the suggested dose of Pomalid is 3mg per day.

In hepatic impaired patients

The advised dose is 3mg/day & in severe condition, the suggested dose is 2mg/day given for mild to moderate patients.

Embryo fetal damage

Pomalid 4mg should be contraindicated to pregnancy causes Teratogenecity, organogenesis and causes fetal damage. Avoid becoming pregnant during Pomalid 4mg therapy by using effective contraceptives.

Venous & arterial thromboembolism

Deep vein thrombosis is risk condition occurs during the Pomalid 4mg treatment. Thromboprophylaxis is initiated for this condition. In case of pembrolizumab given to thalidomide & dexamethasone causes Elevation of mortality Pembrolizumab combined with dexamethasone causes mortality in high range in multiple myeloma condition. The combination of PD-1 or PD-L1 blocking agent with thalidomide analogue with dexamethasone has not evaluated.

Hematological toxicity

Neutropenia, thrombocytopenia is most common adverse effects occur during the Pomalid 4mg treatment. These may negate by checking the blood counts frequently and postponement of dosage or adjustment of dose is necessary.

Liver toxicity

During Pomalid 4mg treatment, there is a chance of elevation of hepatic enzymes occurs. This may results as increased liver toxicity.

Neuropathy

Pomalid 4mg combined with low dose of dexamethasone causes peripheral neuropathy in some patients. Prevent the treatment until toxicity grade chances to 1 or 0 Exposure of second primary malignancies; Pomalid 4mg receiving patients has high chances of getting second primary malignancies.

Tumor lysis syndrome

This condition is majorly occurred in Pomalid 4mg receiving patients. Monitor the manifestation due to this condition Appropriate management should be provided



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Pomalid 4mg DRUG INTERACTION

Pomalid 4mg concurrently used with CYP1A2 drugs causes increased concentration of Pomalidomide. Overcome this problem by reducing the dose of Pomalid 4mg during this combination therapy.

Pomalid 4mg CONTRAINDICATION

Pomalid 4mg is contraindicated to; Pregnancy Lactation Hypersensitivity reactions produced due to patients are contraindicated to the component of Pomalid 4mg .

Pomalid 4mg WARNING

The most probable worsening condition of Pomalid 4mg is; Venous & arterial thromboembolism Embryo fetal damage


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