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Omnacortil 20mg is the first drug of choice for most patients with primary Nephrotic Syndrome. Omnacortil 20mg is indicated for the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Omnacortil 20mg also Indicated to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis.

Omnacortil 20mg also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rheumatic carditis. Omnacortil 20mg also indicated in the treatment of leukaemia’s, lymphomas, thrombocytopenia purpura and autoimmune haemolyticAnemia. Omnacortil 20mg also indicated to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.

Omnacortil 20mg Tablet is aneffectivepreventory of the early phase of inflammation, as well as of the development of chronic inflammation Omnacortil 20mg replaces a chemical made in the body.

It lowers or stops the body’s reaction to the allergen. It stops or lowers irritation and swelling. It lowers the body’s harmful response to diseases of the immune system.

ADME properties Omnacortil 20mg


Omnacortil 20mg absorbs readily in gastrointestinal tract, peak plasma concentration is 1-2 hr after administration.


Very high protein bounding about >90%.


Omnacortil 20mg is mainly metabolised in liver and eliminated in the urine as sulphate and glucuronide


Eliminated from the plasma with a mean. Half-life of the drug is 2-3 hours.


Ingredients : Prednisolone
Strength : 20mg
Package : 10 tablets in 1 strip

Side effects of Omnacortil 20mg

Electrolyte imbalance, Headache, Fragile skin, Decreased libido, Bone degradation, Menstrual cycle alteration, Infection risk increased, Insomnia, Hair growth increased, Muscle disorders, Changes in personality, Menstrual periods absence, Acne, High blood pressure, Redness of skin, Skin scar


Omnacortil 20mg may increase the blood glucose levels and decline the symptoms of diabetes. The patients with diabetes should Use with caution. Tablet may decreased the bone density by reduce the absorption of calcium. Tablet is needed with caution in the patients with liver injury and impaired kidney function.

This medicine should be avoided for pregnant women. This tablet is known to excreted via breast milk in little amounts so not advisable for breast feeder. Tablet may reduce the effect of live or vitiate vaccines.


Drug- drug interaction

Combination with Amino glutethimide may lead to loss of corticosteroid-induced adrenal suppression. There have been cases resulted in which combination of Amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure (see also Potassium depleting agents).

Interaction of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If probably, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy. CYP 3A4 inhibitors Ketoconazole has been resulted to decrease the metabolism of certain corticosteroids by up to 60% leading to an increased risk of corticosteroid side effects.

Omnacortil 20mg interaction with Cholestyramine may increase the clearance of corticosteroids. Patients on taking Omnacortil 20mg interaction with digitalis glycosides may be at increased risk of arrhythmias due to hypokalaemia.


Omnacortil 20mg Orally Disintegrating Tablets are contraindicated in patients who are hypersensitive to corticosteroids i.e. prednisolone or any components of this product. Sometime particular of anaphylactoid reactions have appeared in patients getting corticosteroid therapy.

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