WELCOME TO Million Health Pharmaceuticals
Million-Health-Pharmaceuticals



ADME process

Absorption

After absorption of Ricovir EM , reaches maximum plasma concentration time are; Emtricitabine: 1 to 2 hours; tenofovir DF: 1.0 plus or minus 0.4 hour. The oral bioavailability of tenofovir is occurs by 25%, by administering with food, bioavailability reaches by 40%.

Distribution

Tenofovir has low binding capacity, <0.7% to human plasma proteins & <7.2% to serum proteins. Emtricitabine has low protein binding capacity by less than 4%.

Metabolism

The metabolism of Tenofovir DF not induced by cytochrome isoenzymes The metabolism of Emtricitabine is induced by undergoing biotransformation.

Elimination

The elimination of Ricovir EM is occurs through glomerular filteration & active tubular secretion. The half lives of Ricovir EM is Tenofovir DF: 17 hours with range of 12.0 to 25.7 hours. Emtricitabine: 10 hours with range of 7.4 to 18.0 hours





million-pharma-img1

Brand : Ricovir EM
Ingredients : Tenofovir disoproxil fumarate & Emtricitabine
Strength : 300mg & 100mg
Manufactured : Mylan
Package : 30 Tablets

Dosage & Administration of Ricovir EM

1. Before begin the treatment using with Ricovir EM , patient should be examine thoroughly for presence of HBV infection or not. Hepatic function test & renal function test should be monitored. 2. Patients receiving Ricovir EM for PrEP, screening the HIV-1 infection for once three months.

Dosage recommendation

The advised dose of Ricovir EM for adults & pediatric with weight of at least 35kg is one tablet should be administered as once daily by taking with food or without food.

For PrEP condition

One Ricovir EM tablet should be taken as once daily for both adults & pediatric with weight of at least 35kg.

Dosage adjustment for renal impaired patients

CrCl ≥50ml/min, one tablet should be taken for every 24 hours CrCl 30 to 49ml/min, one Ricovir EM tablet should be taken for every 48 hours CrCl <30ml/min, Ricovir EM tablet should not be recommended

Side effects of Ricovir EM

Lactic acidosis & hepatic steatosis Serious exacerbation of HBV Renal damage Immune reconstitution syndrome Bone defects

Common effects

Headache Insomnia Nasopharyngitis Vomiting Fatigue Depression Nausea Diarrhea Respiratory tract infection Sinusitis Rash

Lab abnormalities

Increased alkaline phosphatase Increased AST & ALT Anemia Increased blood glucose Hematuria Glycosuria Increased cholesterol Elevation of serum lipase Increased creatine kinase Neutropenia

Post marketing effects

Renal & urinary disorders Hepatobiliary disorders Musculoskeletal disorders

Lactic acidosis & hepatic steatosis

This fatal condition is occurs due to increased hepatic enzymes. To prevent this condition by monitoring the hepatic functions & hepatic enzymes levels. In severe condition, Ricovir EM should be stopped.

Due to drug interactions

Some combinational therapy leads to cause severe adverse effects. Ricovir EM should not be combined with Trustiva, Atripla, or Viraday.

HIV-1 & HBV co infection

Due to exposure of advancement of HIV-1 resistance, Ricovir EM should be used in patients who are co infected with HIV-1 HBV by combining with other anti-retroviral drugs. Before initiating the treatment, patient should examined by testing the HIV-1 antibody

Aggravation of HBV infection

This severe fatal case is occurs, after conclusion of anti-hepatitis B treatment. To prevent this effect by monitoring the patient’s hepatic functions before begin the therapy. In final condition, patient should be resuming with anti-HBV therapy.

Bone defects

The major risk of Ricovir EM is loss of bone mineral density. To overcome the problem by providing the vitamin D supplements.

Newly commenced or aggravation of renal impaired patients

To prevent this worsening condition, patients renal function should be examine clearly by measuring the creatinine clearance, urine protein, urine glucose levels. Avoid the concomitant use of Ricovir EM with drugs affecting the renal functions.

Immune reconstitution syndrome

This is most frequently occurred in anti-retroviral agents receiving patients. In this condition, Ricovir EM should be discontinued and provide a supportive measures.

Loss of virological response

During the combination of triple dose regimens, resistance will produced and leads to loss of activity. Monitoring the patients thoroughly while using triple dose regimen, if resistance formed or not.



million-pharma-book1

Warning and precaution

Ricovir EM co administered with HIV-1 protease inhibitors, leads to decreasing the AUC & Cmin value of these protease inhibitors. Avoid the concomitant of Ricovir EM with protease inhibitors. Ricovir EM combines with hepatitis C viral agents, causes elevation of risk of tenofovir by increasing its concentration. Ricovir EM combines with drugs affecting the renal functions causes increasing the concentration of component of Ricovir EM and increase the risk associated with Ricovir EM . Ricovir EM combined with Didanosine causes increasing effect of concentration of Didanosine and leads to elevating the adverse effects related to Didanosine.

Contraindications

Ricovir EM for PrEP is contraindicated to patients with unidentified or positive HIV-1 satus. Hypersensitivity reactions are formed if patients are contraindicated to component of Ricovir EM .


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.