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Fast absorption from the GI tract, absorption increased with food, peak plasma concentration is approx 2-4hr.


Minimal amount distribution enters into CNS, volume of distribution about 0.16-0.66 L/kg. binding of plasma protein is approx 98%.


Ritomune is mainly metabolized in liver by CYP3A4 & lesser extent by CYP2D6 isoenzymes.


Ritomune exceted by both unchanged and metabolite via faeces approx 86% and 3.5% as unchanged drug via urine approx 11%. The terminal elimination half life is 3-5hr.


Brand : Ritomune
Ingredients : Ritonavir
Strength : 100mg
Manufactured : Cipla
Package : 60 Tablets


GI effects: abdominal pain, nausea, vomiting, diarrhea, anorexia Common side effects: asthenia, taste disorder, headache, numbness or tingling around the mouth or extremities, anxiety, insomnia, fever, dizziness, malaise, hyperaesthesia, pharyngitis, rash, pruritus, sweating, vasodilatation, wt loss, Allergic reactions : urticaria, bronchospasm, angioedema, mild skin eruptions, immune reconstitution syndrome, lipodystrophy, osteonecrosis, Metabolic abnormalities: hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycaemia, hyperlactataemia. Reduced levels of Hb, K, free and total thyroxine; increased eosinophil, liver enzymes, amylase and uric acid; reduced or increased WBC and neutrophil counts. Major side effects: Pancreatitis, hepatic dysfunction, Stevens-Johnson syndrome. Rarely, anaphyla.



In drug Ritomune will Increased plasma conc of certain drugs highly metabolized by CYP3A . Ritomune interaction with phenobarbital, carbamazepine, dexamethasone, phenytoin, rifabutin and rifampicn will decrease the plasma concentration. Increased plasma concentration of certain drugs highly metabolized by CYP3A. Ritomune interaction with sildenafil leads to serum levels of sildenafil increase. Serious risk: Avoid contemporaneous admin of oral solution (contains alcohol) with disulfiram / metronidazole. Ritomune with simvastatin or lovastatin increased risk of myopathy. Concurrent use Ritomune with alfuzosin may lead to serious hypotension.


Before taking Ritomune , inform your doctors about as follows: Patient with ischaemic heart disease, cardiomyopathy, pre-existing conduction abnormalities or structural heart disease, haemophilia A or B, porphyria, increased triglycerides. Renal and severe hepatic impairment without decompensation in Childern& Pregnancy. Monitoring Parameters Monitor cholesterol, triglycerides, CBC, LFTs, creatine phosphokinase, uric acid,viral load,CD4 count, serum amylase and lipase, glucose.

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