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Rolimus 10mg tablets are mainly indicated for the treatment of Renal carcinoma. Rolimus 10mg tablets are mainly indicated for the treatment of Breast carcinoma. Rolimus 10mg tablets are mainly indicated for the treatment of Brain carcinoma. Rolimus 10mg is also used in various advanced stage cancer in stomach, intestines or pancreas.

Everolimus is an mTOR prohibitor, joints at high compatibility to FK506 binding protein 12, via producing drug complex which inhibits the specific of mTOR. This inhibition decreases the activity of effectors downstream, that may cause blockage of cell progression from G1 into S phase, subsequently causes cell growth arrest and apoptosis

ADME properties


The high plasma concentration time of Everolimus is 1 to 2 hours. The effect of food with Rolimus 10mg that with heavy meal: Reduction of systemic exposure to Rolimus 10mg 10mg, and the high blood plasma concentration by 54%.


Rolimus 10mg human plasma protein bound with the range of 74%.


The metabolism of Everolimus is occurred in liver, which is a substrate of CYP3A4. The metabolites of Everolimus; Three monohydroxylated metabolite, Two hydrolytic rings opened products, & Phosphatidylcholine conjugate of Everolimus.


The major route of elimination; 5% in urine; the parent compound has been detected in urine or feces. The half-life period of Everolimus is relatively 30 hours


Brand : Rolimus
Ingredients : Everolimus
Strength : 10mg
Manufactured : Cipla
Package : 10 tablets in 1 strips


In breast cancer, renal cell cancer, pancreatic cancer, Neuro endocrine cancer: The prescribed dosage is 10mg should be taken as a single dose. In Brain or intracranial cancer: The prescribed dosage of Rolimus is 4.5mg/m2 orally as a single dose. In pediatric: The usual pediatric dosage of Rolimus in brain or intracranial tumor is 4.5mg/m2 should be taken orally as a single dose. Rolimus tablets should be administered with or without food.


The over dosage of Everolimus is rarely occur, in case of over dosage patient must be provide with supportive measures. The acute toxicity of Everolimus over dosage should be monitored.


Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes


Increased exposure of skin cancers, patient may protect from UV light

Serious infections

Patients receiving Rolimus 10mg have high risk of acquiring various infections related to bacteria, virus, and fungi. Anti-microbial agents are preferred for the suspected patients.

Hepatic artery thrombosis

In liver transplant patients, Rolimus 10mg therapy should not be recommended.


Renal function should be monitored frequently; caution should be taken while using Rolimus 10mg in renal impaired patients.


This may have occurred in the patients receiving concomitantly Rolimus 10mg with Angiotensin converting enzyme agents


Patient getting Rolimus 10mg with lipid lowering drugs causes increasing in plasma concentration of these drugs causes hyperlipidemia

Interstitial lung disease

Occurred in Rolimus 10mg therapy

Interact with grape juice

Causes increasing blood levels of Everolimus; avoid these concomitants.



Rolimus 10mg interaction with strong inhibitor of CYP3A4, or P-gp, leads to cause decreasing the efflux of Everolimus and increase the plasma concentration of Everolimus. Combination of Rolimus 10mg with verapamil leads to increasing the plasma concentration of Everolimus.

Combination of Rolimus 10mg with Atorvastatin or pravastatin causes rhabdomyolysis, due to increasing concentration of lipid lowering agents. Rolimus 10mg combination with strong CYP3A4 inducers, causes increasing the exposure of Everolimus.

Concomitant use of Rolimus 10mg with cyclosporine causes increasing the AUC level of Everolimus frequently. Rolimus 10mg tablet is interaction with ketoconazole or other CYP3A4 inhibitors causes increasing the plasma concentration and AUC of Everolimus. Concomitant use with erythromycin causes increasing in AUC of Everolimus.


Some anaphylactic reaction occurs, if patients are contraindicated to the components present in the Rolimus 10mg tablets.

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