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Sofovir mechanism


The components in Sofovir tablets are involved in inhibiting non structural protein which is essential for viral multiplication. Sofosbuvir is a NS5B inhibitor, Sofovir is a directly acting anti-hepatitis C viral agent. Sofosbuvir leads to produce pharmacologically active uridine analog triphosphate by intracellular metabolism. Sofosbuvir is inserted into viral HCV DNA by NS5B polymerase and act as a chain terminator.

ADME property

The peak plasma concentration time of Sofosbuvir is 0.5 to 1 hour respectively. The effect of food with Sofovir tablet determines as; With moderate meal: Sofosbuvir increases to 60%; increases to 34% With high fat meal: Sofosbuvir increases to 78%; increases to 21% Flowing metabolite high serum time is between 2 to 4 hours

The human plasma protein bound; Sofosbuvir is 61 to 65%. The metabolism of Sofovir occurs; Sofosbuvir: cathepsin A, or carboxyl esterase The elimination of Sofovir occurs via;

SThe terminal half life of Sofovir tablets; Sofosbuvir: 0.5 hours; GS331007: 25 hours Elimination of Sofosbuvir in urine at 80%; feces at 14% ofosbuvir: Glomerular filtration, active tubular secretion


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Brand : Sofovir
Ingredients : Sofosbuvir
Strength : 400mg
Manufactured : Hetero
Package : 28 Tablets

In adults

400mg of Sofovir The prescribed dose of Sofovir by blend with different meds; Considerate obtain with genotype I, IV, V or VI ceaseless hepatitis C viral disease: Sofovir is joined with ribavirin and peg interferon alfa ought to be taken as a once a day. Sofovir and ribavirin ought to be taken if there should be an occurrence of patients are bothersome to take peg interferon alfa.

Patients endured with genotype II ceaseless hepatitis C

Sofovir ought to be joined with ribavirin as a solitary dose Patients with genotype III hepatitis: Sofovir joined with ribavirin and peg interferon alfa and it ought to be taken as a solitary dose Generally Sofovir with ribavirin ought to be taken as single dose In liver transplantation: Sofovir ought to be simultaneously utilized with ribavirin as a single dose until liver transmission.

In pediatric

The usual dose Sofovir tablet for the children at age 12 or weight of at least 35kg; Without cirrhosis or with child Pugh A or compensated in patients: One tablet of Sofovir should be combined with weight based ribavirin as a single dose given for 12 weeks. For the patients with decompensated cirrhosis: Combine with ribavirin for 24 weeks the patients should be used One tablet The dosage of ribavirin; Based on body weight of the patients, the dosage of ribavirin should be recommended. < 75kg given 1000mg of ribavirin. At least 75kg given 1200mg of ribavirin. Ribavirin must be administered with food. Dosage adjustment should not be recommended in renal and hepatic impairment patients.

Sofovir causes undesirable effects

Headache Fatigue Nausea Asthenia Insomnia Anemia HBV reactivation Elevation of lipase & amylase levels Elevation of creatine kinase Cardiac disorder like bradycardia while concomitant with amiodarone Angioedema Skin rashes

Sofovir precautions

Exposure of hepatitis B viral infection occurs in HBV/HCV co infections Serious symptomatic bradycardia while concomitant with amiodarone Risk of depletion of therapeutic effect occurs due to combination of Sofovir with P-gp inducers or CYP3A4 inducers Fetal adverse occurs while concomitant with ribavirin For all these conditions, withhold or discontinue the therapy with Sofovir tablets.



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Sofovir drug interaction

Sofovir is a substrate of P-gp and BCRP transporters. While utilizing Sofovir with P-gp or BCRP solid inducers like rifampicin or st Johns wort may causes diminishing the plasma convergence of Sofovir . Accordingly the outcomes consumption of restorative impact of Sofovir Sofovir co organization with P-gp or BCRP inhibitors, causes expanding the plasma convergence of Sofovir Sofovir with comforting medication like modafinil causes diminishing the impact of grouping of Sofovir .

While joining with Sofovir with amiodarone, no impact of fixation happens yet symptomatic bradycardia happens Sofovir with vitamin K rival, vary the impact of vitamin K adversary Sofovir with anticonvulsants like phenytoin, Phenobarbital or carbamazepine causes diminishing the impact of Sofovir Sofovir with hostile to mycobacterials causes consumption essentially of grouping of Sofovir

Sofovir contraindicated to

Sofovir is contraindicated to patients who are taking in combination with ribavirin. Ribavirin is contraindicated to pregnancy condition.




abdominal pain
abdominal pain
concluded as death
concluded as death
dark urine
dark urine
fatigue
fatigue
flu like syndrome
flu like syndrome
loss of apetite
loss of apetite
loss of weight
loss of weight


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