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PHARMACOKINETIC

Absorption

Rapidly absorped with maximum plasma concentrations occurring within 1 hour after dosing.

Distribution

Human plasma protein bounding is negligible

Metabolism

The active substrate for HIV- reverse transcriptase is phosphorylated intracellularly to Stavudine triphosphate.

Excretion

Stavudine administrating to healthy subjects following 80mg dose then the total radioactivity was eliminated in urine 95% and feces 3% respectively.

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Brand : Stavir
Ingredients : stavudine
Strength : 30mg
Manufactured : Cipla
Package : 60 Tablets

Dosage and administration

The prescribed dose of the adult for the treatment of HIV infection
The dosage is mainly based on body weight as follows: The patients weighing < 60kg administer 30mg every 12 hours The patients weighing at least 60kg administered 40mg every 12 hours

Prescribed dose for pediatrics
0.5mg/kg given 12 hours for newborns from birth to 13 days old. 1mg/kg given every 12 hours for pediatric patients at least 14 days old And weighing < 30 kg. Use same adult dose for pediatric patients weighing at least 30kg

Over dosage
The recommended daily dosage exposes no acute toxicity. The chronic dosage complication involves peripheral neuropathy and hepatic toxicity by hemodialysis Stavudine can be removed.

Drug interaction

Combination with zidovudine will competitively prohibits the intracellular phosphorylation of Stavudine . Stavir concomitant use with doxorubicin should be taken with caution, it will leads to the phosphorylation of Stavudine is inhibited at relevant concentrations by doxorubicin. While Stavir interaction with ribavirin will reduces phosphorylation of Lamivudine, Stavudine and zidovudine.

Contraindication

In patients Stavir capsules is contraindicated with hypersensitivity to Stavudine or to any of the components.





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Precaution

Lactic acidosis
Severe hepatomegaly with steatosis and lactic acidosis with the use in combination or nucleoside analogues involves stavudine and other antiretrovirals.

Hepatic toxicity
HIV patients with significant underlying liver disease, the safety and efficacy of stavudine have not been established. If combination with antiretroviral therapy, some serious problem arises and potentially fatal hepatic adverse events and should be checked according to standard practice.

Fat redistribution
Redistribution/aggregation of body fat involving central obesity, dorsocervical fat augmentation (buffalo hump), peripheral wasting, facial wasting, breast enlargement, and “cushingoid appearance” have been observed in patients getting antiretroviral therapy.

Neurologic symptoms
Motor weakness has been resulted rarely in patients getting combination with antiretroviral treatment involving Stavudine and patients should be monitored for the growth of peripheral neuropathy.


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