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Drug interaction

Tacrograf 0.25mg is metabolized by CYP3A enzymes, by inhibiting these cytochrome enzymes leads to increasing plasma concentration of Tacrograf 0.25mg
CYP3A inducers: may decrease the concentration of Tacrograf 0.25mg
Mycophenolic acid products: increase exposure to Mycophenolic acid
Grape fruit/grape fruit juice: this will prohibit CYP3A enzymes, leads to increase the Tacrograf 0.25mg whole blood trough concentrations Protease inhibitors: increase the concentration of Tacrograf 0.25mg
Anti-fungal agents: depending on whole blood concentration of Tacrograf 0.25mg, anti-fungal drugs are used. While concomitant voriconazole or posaconazole with Tacrograf 0.25mg, the dose of Tacrograf 0.25mg decreased to one-third of initial dose
Calcium channel blockers: inhibit CYP3A enzymes, increase the concentration of Tacrograf 0.25mg
Anti-bacterial: erythromycin, clarithromycin, troleandomycin, chloramphenicol are inhibit CYP3A enzyme, leads to elevate concentration of Tacrograf 0.25mg
Anti-mycobacterial: are rifampin and rifabutin; induce CYP3A enzymes causes decrease the Tacrograf 0.25mg concentration
Anti-convulsant: decrease the concentration of Tacrograf 0.25mg
St. Johns wort: decrease the concentration of Tacrograf 0.25mg
Gastric acid regulator and suppressor: increase the concentration of Tacrograf 0.25mg

Contraindication

Hypersensitivity reaction or anaphylactic reactions occurs






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