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PHARMACOKINETIC

Absorption

Tafero EM ; the absorption of tenofovir is occur fastly and its Tmax is observed at 1 hour after administration; whereas Emtricitabine is absorbed rapidly and its mean bioavailability is 93%

Distribution

The human plasma protein bound of Emtricitabine is very low less than 4% Tenofovir is highly bound to human plasma protein with the range of 80%

Metabolism

TAF, is hydrolyzed into tenofovir within the cells, it is the major metabolite again phosphorylated into tenofovir diphosphate active metabolite Emtricitabine is metabolized minimally and it is found in urine as unchanged form

Excretion

The route of elimination mostly through urine The terminal half life of Emtricitabine is 10 hours The terminal half life period of tenofovir is 0.51 hour



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Brand : Tafero EM
Ingredients : Tenofovir Alafenamide Fumarate and Emtricitabine
Strength : 25mg & 200mg
Manufactured : Hetero
Package : 30 Tablets

DOSAGE AND ADMINISTRATION

The prescribed dose of Tafero EM in the condition of HIV-1 infection in adults is, one tablet should be taken once daily with or without food. In Pre-exposure Prophylaxis: uninfected adults should take one tablet orally as a single dose.

General

Diarrhea, nausea, fatigue, headache, dizziness, depression, insomnia, abnormal drms

Metabolic

Increased fasting cholesterol, decreased phosphorus, increased fasting triglycerides, altered serum glucose, weight loss, hyperglycemia, increased alkaline phosphatase, lactic acidosis severe hepatomegaly

Hepatic

Increased AST and ALT, hepatic steatosis, lactic acidosis, increased bilirubin, severe acute exacerbation of hepatitis B

Blood

Decreased neutrophils and hemoglobulin

Respiratory

Pharyngitis, sinusitis, upper respiratory tract infection, Nasopharyngitis, increased cough, pneumonia, rhinitis

Gastrointestinal

Increased serum amylase, abdominal pain, pancreatitis, increased serum lipase

Psychiatric

Depression, insomnia, anxiety

Nerve system

Headache, somnolence, peripheral neuropathy

Others

Fatigue, syphilis, pain, fever, asthenia, high vitamin D levels

Skin

Rashes, skin discoloration, lipodystrophy, angioedema, sweating

Genitourinary

Proteinuria, urethritis, urinary tract infection, Hematuria, genital ulceration, anogenital warts Polyuria, glycosuria

Immune

Immune reconstitution/reactivation syndrome, autoimmune disorders

Hypersensitivity

Allergic reaction

Endocrine

High serum parathyroid hormones



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Tafero EM Drug interaction

Acyclovir-valaciclovir: increase the serum concentration of tenofovir Adefovir: decrease the therapeutic effect of tenofovir Amino glycosides: increase the serum concentration of tenofovir Carbamazepine: decrease the serum concentration of tenofovir Cidofovir: increase the serum concentration of tenofovir Cobicistat: may increase the toxic effects of tenofovir Diclofenac: may enhance the nephrotoxicity effect of tenofovir Fosphenytoin/phenytoin: decrease the serum concentration of tenofovir Lamivudine: increase toxic effects of Emtricitabine NSAIDS: increase the nephrotoxicity effect of tenofovir Orlistat: decrease the serum concentration of anti-retroviral drugs Oxcarbazepine, Phenobarbital, primidone, rifabutin, rifampin, rifapentine, st. Johns wort, tipranavir these are the drugs which involved in depletion of serum concentration of tenofovir

Tafero EM Contraindication

Tafero EM should not be used in persons with unknown or positive 1 status. Tafero EM not used as monotherapy, it is used with other retroviral medicine. Hypersensitivity in lactation


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