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Taffic is a combination tablet contains Tenofovir Alafenamide, Emtricitabine & Bictegravir is mainly determined for the medication of HIV-1 infection in adult’s patients.

Taffic is a nucleoside reverse transcriptase inhibitor (carboxylic synthetic nucleoside analog), it has activity against human immunodeficiency virus type I. OH, molecules are vital for the formation of 5’ to 3’ phosphodiester linkage which is guilty of chain extension.
This active metabolite forbids the action of reverse transcriptase by spar with dGTP and inserted into viral DNA. The growth of viral DNA gets concerned by the infusion of nucleotide which causes lack of OH molecule. Taffic is phosphorylated into an active metabolite carbovir triphosphate (deoxyguanosine 5’triphosphate) dGTP.

Brand : Taffic
Ingredients : Tenofovir Alafenamide + Emtricitabine + Bictegravir
Strength : 25mg + 200mg + 50mg
Manufactured : Hetero
Package : 30 Tablets


The recommended dose of Taffic is one tablet that should be given orally as day-to-day.The patient’s renal values should be considered for the creatinine confirmation, urine glucose & urine protein.Taffic should not be suitable for patients with creatinine approval below 30ml/min.
important points; before starting the treatment, the patient should be considered for the presence of hepatitis B infection or not.Taffic tablets should be executed with food or without food.Taffic should be used in adolescents, a pediatric patient with weighing at least 25kg & creatinine approval of patients should be larger or similar to 30ml/min.


Common side effects:
• Distress
• Abnormal dreams
• Headache
• Dizziness
• Diarrhea
• Feeling sick (nausea)
• Tiredness (fatigue)
Uncommon side effects:
• Anemia
• vomiting
• Stomach pain
• Difficulty with digestion resulting in discomfort after meals (dyspepsia)
• wind (flatulence)
• swelling of the face, lips, tongue or throat (angioedema)
• itching (pruritus)
• Careless
• Joint pain (arthralgia)
• Suicidal behavior
• Tension
• sleep disorders


Immune reorganization syndrome: To overcome the problem by interfering withthe treatment with Taffic.
The domination of Taffic tablets for growing HIV-1 infection has not been assessing.
These assets mostly happen in patients who are HIV-1 co-infected. Renal deterioration exacerbates: Stop using Taffic with drugs affecting the renal functions. Lactic acidosis & hepatic steatosis: Terminate the therapy using Taffic Monitor the creatinine clearance value frequently. In serious conditions, CrCl below 30ml/min use of Taffic should be avoided. The frustration of HIV-1 infection: Patients should be treated earlier for the growth of HIV-1 infection or not.


Drug interactions

Taffic + P-GP or BCRP potent inhibitors: affect the utilization of TAF. Taffic + potent P-gp or BCRP inducers: decrease the consumption of TAF causes reducing=g the plasma combination of TAF and certainly results as loss of influence of Taffic.
Taffic expulsion process occurs through kidneys; a combination of Taffic with drugs affecting the renal activity causes increasing the effect of concentration of ingredients of Taffic& concludes as an attain of adverse effects associated with these components. Taffic combines with drugs like Tipranavir/Ritonavir causes a decline in the effect of the concentration of TAF.
Taffic concurrently used with anti-convulsions causes decreasing the effect of concentration of TAF. Taffic concurrently used with anti-mycobacterium or stJohn’s wort causes decreasing the effect of concentration of TAF. Inhibition of both CYP3A4 and UGT1A1 by a co-administered drug could potentially lead to significant increases in BIC exposure, while potent induction of these enzymes may significantly reduce BIC exposure.

contraindicated to

Taffic has differed to patients with CrCl below 30ml/min Anaphylactic reactions are develop due to patients are contraindicated to the cause of Taffic.

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