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ADME process

Absorption

Rapid absorbed from GI tract, bioavailability (25%) The time to peak plasma concentration of Tavin is 1-2hrs.

Distribution

the drug bounding of human serum protein is >1% and it is widely distributed into body tissue especially in kidney and liver ( volume of distribution is 1.2-1.3L/kg).

Metabolism

TenofovirDisoproxil Fumarate is converted into Tavin through hydrolysis by cellular enzyme through phosphorylation. and to form active Tavin diphosphate . ELIMINATION: By active tubular secretion and glomerular Tavin excreted via urine. Half life of Tavin is 18hr.


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Brand : Tavin
Ingredients : Tenofovir Disoproxil Fumarate
Strength : 300mg
Manufactured : Emcure
Package : 30 Tablets

DOSAGE AND ADMINISTRATION

In adult 12yrs and older: 300mg If patient not able to shallow take oral powder formulation of 7.5 scoops In pediatric 2yrs and <12yrs : 8 mg recommended dose. If patient not able to shallow take oral powder formulation is 1 level scoop=1 g powder contains 40mg of Tavindisoporxil. ≥ 17kg Tavin dos available in different strengths 150, 200, 250 and 300mg. One tablet of Tavin 300mg, once daily without food, taken orally.

OVERDOSAGE

The drug has no severe adverse reaction for effect of higher dose and treatment provides of general supportive measures involves monitoring of evidence of toxicity and patients clinical status observation.

SIDE EFFECTS

Common effects

Mild nausea, stomach ache, insomnia, itching and rashes, Change in body shape (fat) Signs of allergic reaction Hives, Dyspnea, Swelling of (face,lips,throat,tongue) Severe hepatomegaly with steatosis Chest pain Wheezing Cold sore Fast heart rate Lumbar pain

DRUG INTERACTION

When Tavin interaction with didanosine and HIV-1 protease inhibitors then increase didanosine concentration and results in adverse effects like pancreatitis and neuropathy Interaction with HIV-1 protease inhibitors such as atazanavir will reduces atazanavir concentration while increase the Tavin concentrations



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Warning and precaution

Hepatomegaly suffering patients or other severe factors for liver problem.Renal impairment. Pregnant women Patient Counselling Tavin may cause dizziness, do not drive or operate machinery.

Renal function and serum phosphate concentrations prior to therapy, 4 wkly in 1st wk, and then 3 mthly; hepatic function for several month following discontinuation. Determine HIV condition in all hepatitis B virus (HBV) infected patients before treatment. Allergy to Tavin or any other drug.Before inform with doctor about allergic to any drugs. Such as rash; hives; itching; Dyspnea; wheezing; cough; swelling of (face, lips, tongue, or throat); or any other signs.

If you had kidney or liver disease and taking colchicines then inform your doctor, he may stop the Tavin drug. Inform your doctor that you are pregnant or plan for pregnancy or breast feeding, while you infected with HIV or taking Tavin tablet avoid breast feed.


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