WELCOME TO Million Health Pharmaceuticals
Million-Health-Pharmaceuticals



Pharmacokinetics

Absorption

After absorption of Tenofovir tablets, the mean oral bioavailability is reaches by almost 25% and Lamivudine is 86% plus or minus 16% by very quick absorption. The Tenofovir peak serum concentration time occurs in 1 hour plus or minus 0.4 hours. Tenvir L administered with food, causes elevation of oral bioavailability by almost 40%.

Distribution

Tenofovir get bounds to human plasma protein or serum proteins by less than 0.7 & 7.2% respectively. Lamivudine get binds to human plasma protein by <36%

Metabolism

No cytochrome isoenzymes are involved in the metabolism of Tenofovir. Lamivudine get metabolized by undergoing biotransformation.

Excretion

The elimination of Tenofovir occurs via glomerular filteration & active tubular secretion. After oral administration of single dose of Tenofovir, reaches half life period at almost 17 hours. Nearly 70 to 80% of dose gets eliminated via urine & feces. Lamivudine eliminated by urine and half life of Lamivudine: 5 to 7 hours







million-pharma-img1

Brand : Tenvir L
Ingredients : Tenofovir disoproxil Fumarate and Lamivudine
Strength : 300mg + 300mg
Manufactured : Cipla
Package : 30 Tablets

Dosage & Administration of Tenvir L

The Tenvir L recommended dose for adult suffering from HIV infection The administrated one tablet orally given onace a day with combination of other antiretroviral agents. In pediatric patients dose: The patients should weighing atleast 35kg administrated one tablet given once a day via orally with combination of other antiretroviral agents.

Overdosage

There are no known specific treatment for 3TC overdose, If occurs patients should monitored and provide supportive treatment because negligible 3TC amount was removed through 4 hours hemodialysis and Tenofovir clinical experience of overdose is limited

The most common adverse effects are

Serious acute aggravation of hepatitis New commencement of worsening bone pain Muscle weakness Arms, hands ,leg or feet pains Swelling around your midsection Kidney problem such as no urination, feet and ankles swelling Signs of liver and pancreas problem Appetite decreased, upper stomach painclay-stools. Signs of new infection : fever, sweaing at night, swollen glands,weight loss

Common side effects

Headache Pain Diarrhea Rash depression

Aggravation of hepatitis infection

After conclusion of treatment, patients may suspect with worsening of HBV infection condition. Patient infected with HBV condition should be monitored frequently after discontinuing the HBV anti-viral therapy. In this condition, patient should be resuming the anti-HBV treatment.

New outbreak or worsening of renal damage

Avoid combination of Tenvir L with drugs affecting the renal function. Monitor the renal function by measuring the creatinine clearance, serum protein, serum glucose levels.

Lactic acidosis & hepatic steatosis

This condition should be takes place due to imbalance level of hepatic enzymes. To overcome the problem by monitoring the hepatic function test In severe condition, therapy should be discontinued.

Drug interactions

Some drugs may interact with activity of Tenvir L and produced adverse effects. In some condition, over dosage or duplication of therapy should be occurred. Avoid the combination of Tenvir L with Trustiva, Viraday or Atripla.

HIV-1 & HBV co infection

Before initiating Tenvir L treatment in co infected patients, HIV-1 antibody testing should be undergone. Examine the HIV-1 infected patients thoroughly whether they are co infected with HBV infection or not.

Bone defects

During tenofovir DF receiving condition, patients bone mineral density will be drops and causes bone related defects like osteomalacia. To overcome the problem by maintain the calcium levels in the body by supplying vitamin D supplements.

Immune reconstitution syndrome

During anti-retroviral treatment, patients must acquire this fatal case. In this condition, discontinue the treatment.

Virologic failure

Increased resistance condition leads to loss of virological responses. Caution should be taken during receiving the triple dose regimen. Monitor the patient’s resistance capacity frequently during the therapy.



million-pharma-book1

DRUG INTERACTION

Tenvir L can harm your kidneys, specifically if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, or pain or arthritis (including aspirin, Tylenol, Advil, and Aleve).

Interaction with HIV-1 protease inhibitors may decrease Tenofovir AUC. Hence avoid CIMDUO should be discontinued Interaction with hepatitis C drugs may shown to increase Tenofovir exposure Other drugs may affect Tenvir L , involving prescription and over-the-counter medicines, vitamins, and herbal products.

Tell your doctor about all your current medicines and any medicine you start or stop using.

Contraindications

No possible contraindication occurs Some hypersensitivity reactions are produced, if patients are contraindicated to ingredients of Tenvir L .


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.