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Drug interactions

Tvaptan combination with moderate CYP3A4 inhibitors will increase in exposure of Tvaptan 30mg.
Combination of lovastatin, digoxin, furosemide, and hydrochlorothiazide has no clinically relevant impact on the exposure to Tvaptan 30mg When interaction with P-gp inhibitors will have reductions in the dose of Tvaptan 30mg
Concomitant use of rifampin and Tvaptan 30mg decrease exposure to tolvaptan by 85%.
Tvaptan 30mg co administration with strong CYP3A4 inhibitors like ketoconazole will have highest labelled dose would be normal to cause an even heavy increase in exposure.

Contraindicated to

Tvaptan 30mg is contraindicated with following condition as
• Patients with autosomal dominant polycystic kidney disease because the drug causes severe and possible fatal liver injury.
• Required in acutely raised serum sodium
• Patients inability to sense
• Hypovolemic /hyponatremia


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