The major indication of valacyclovir is used in the condition like;
Herpes simplex & herpes zoster
Valtrex 500mg is mostly indicated for the treatment of cold sores by Herpes Labialis. Valtrex 500mg have capability to started after the advancement of clinical signs of cold sore has not been evaluated. Valtrex 500mg is likewise determined in the condition like starting scene of genital herpes in immune capable grown -ups. Valtrex 500mg is also indicated in the treatment of relapsed episodes of genital herpes in immuno competent episodes. Valtrex 500mg is exhibit for cutting edge suppressive therapy of repetitive scenes of genital herpes in immuno skillful and HIV-1 contaminated grown-ups. Valtrex 500mg is also used for the contraction of transmission of genital herpes in immuno competent adults. Valtrex 500mg is indicated in the treatment of herpes zoster in immuno competent adults.
In pediatric patients, Valtrex 500mg is includes in the therapy of cold sores with the age of greater or equal to 12 years. Valtrex 500mg is also indicated for the therapy of chicken pox in immuno competent pediatric patients with age of 2 to less than 18 years
Valacyclovir which represented as a prodrug that will go through phosphorylation by using viral thymidine kinase enzyme for changing of acyclovir triphosphate, an active metabolite. This active molecule is included in the prevention of herpes viral DNA replication by competitive inhibition of viral DNA polymerase. After injected of this metabolite into the virus &causes terminate of the developing viral DNA chain. Valacyclovir contains; TheDNA synthesis blocked Destabilizing the strand Prevention of new viral growth
Ingredients : valacyclovir
Strength : 500mg
Pack : 3 tablets in a carton
Valtrex 500mg tablet should be administered with or without food.
The prescribed dose of Valtrexis 2 grams should be taken for two times a day for one day in 12 hours apart.Genital herpes (initial episode)
The prescribed dose of Valtrexis 1 grams should be taken as twice daily for 10 days.Recurrent episode
The prescribed dose is 500mg should be administered orally as twice daily for 3 days.Suppressive treatment
In ceaseless suppressive treatment, the recommended measurements is 1 gram taken as once every day in patients with typical capacities. In patients with 9 repeats for every year, the recommended dosage is 500mg ought to be regulated as once day by day.
500mg of Valtrexshould be administered orally as two times a day.Reduction of transmission
500mg of Valtrexshould be taken as once daily.Herpes zoster
In this condition, the recommended dose of Valtrex 500mg is 1gm should be given as three times a Day for 7 days.In pediatrics
The patient’s age of greater or equal to 12 years, the recommended dose of Valtrexis 2 grams should be taken as twice daily for 1 day.Chicken pox
20mg/kg of Valtrexshould be administered orally as three times a day for 5 days. The maximum dose per day is not exceeding 1-gram 3times a day.
Thrombotic thrombocytopenia purpura/hemolytic uremic syndrome, Acute renal failure, Central nervous effectsThe common side effects
Low RBC Increased AST Neutropenia Respiratory tract infection Decreased platelet counts Nasopharyngitis Headache Dizziness Nausea Abdominal painPost marketing effects
Visual abnormalities Liver enzyme abnormality Hepatitis Renal failure Aplastic anemia Erythema multiforme Alopecia Facial edema High blood pressure Tachycardia Anaphylactic reactions CNS disorders
No drug- drug interactions occurs in the valacyclovir treatment.