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The major indication of valacyclovir is used in the condition like;
Herpes simplex & herpes zoster
In adults
Valtrex 500mg is mostly indicated for the treatment of cold sores by Herpes Labialis. Valtrex 500mg have capability to started after the advancement of clinical signs of cold sore has not been evaluated. Valtrex 500mg is likewise determined in the condition like starting scene of genital herpes in immune capable grown -ups. Valtrex 500mg is also indicated in the treatment of relapsed episodes of genital herpes in immuno competent episodes. Valtrex 500mg is exhibit for cutting edge suppressive therapy of repetitive scenes of genital herpes in immuno skillful and HIV-1 contaminated grown-ups. Valtrex 500mg is also used for the contraction of transmission of genital herpes in immuno competent adults. Valtrex 500mg is indicated in the treatment of herpes zoster in immuno competent adults.
In pediatrics
In pediatric patients, Valtrex 500mg is includes in the therapy of cold sores with the age of greater or equal to 12 years. Valtrex 500mg is also indicated for the therapy of chicken pox in immuno competent pediatric patients with age of 2 to less than 18 years

Valacyclovir which represented as a prodrug that will go through phosphorylation by using viral thymidine kinase enzyme for changing of acyclovir triphosphate, an active metabolite. This active molecule is included in the prevention of herpes viral DNA replication by competitive inhibition of viral DNA polymerase. After injected of this metabolite into the virus &causes terminate of the developing viral DNA chain. Valacyclovir contains; TheDNA synthesis blocked Destabilizing the strand Prevention of new viral growth




PHARMACOKINETICS

Absorption

After oral intake of Valtrex, valacyclovir is fast absorbed from the gastrointestinal tract and bioavailability by 54.5% plus or minus 9.1%.

Distribution

After absorption occurs, the human serum protein binding capacity is 13 to 18%.

Metabolism

Valacyclovir is rapidly absorbed and approximately 99% of drug get changes into an active form like acyclovir & L-valine by sustaining first pass metabolism & hepatic metabolism by enzymatic hydrolysis.

Elimination

About 89% of radioactivity gets excreted via urine. The medianvalacyclovir half-life period occurs in 2.5 to 3.3 hours.



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Brand : Valtrex
Ingredients : valacyclovir
Strength : 500mg
Manufactured : GSK
Pack : 3 tablets in a carton

Valtrex 500mg tablet should be administered with or without food.

In adults
Cold sore (herpes labialis)

The prescribed dose of Valtrexis 2 grams should be taken for two times a day for one day in 12 hours apart.

Genital herpes (initial episode)

The prescribed dose of Valtrexis 1 grams should be taken as twice daily for 10 days.

Recurrent episode

The prescribed dose is 500mg should be administered orally as twice daily for 3 days.

Suppressive treatment

In ceaseless suppressive treatment, the recommended measurements is 1 gram taken as once every day in patients with typical capacities. In patients with 9 repeats for every year, the recommended dosage is 500mg ought to be regulated as once day by day.

In HIV-1 infected patients

500mg of Valtrexshould be administered orally as two times a day.

Reduction of transmission

500mg of Valtrexshould be taken as once daily.

Herpes zoster

In this condition, the recommended dose of Valtrex 500mg is 1gm should be given as three times a Day for 7 days.

In pediatrics
Cold sores (herpes labialis)

The patient’s age of greater or equal to 12 years, the recommended dose of Valtrexis 2 grams should be taken as twice daily for 1 day.

Chicken pox

20mg/kg of Valtrexshould be administered orally as three times a day for 5 days. The maximum dose per day is not exceeding 1-gram 3times a day.

The major adverse effects of Valtrex are

Thrombotic thrombocytopenia purpura/hemolytic uremic syndrome, Acute renal failure, Central nervous effects

The common side effects

Low RBC Increased AST Neutropenia Respiratory tract infection Decreased platelet counts Nasopharyngitis Headache Dizziness Nausea Abdominal pain

Post marketing effects

Visual abnormalities Liver enzyme abnormality Hepatitis Renal failure Aplastic anemia Erythema multiforme Alopecia Facial edema High blood pressure Tachycardia Anaphylactic reactions CNS disorders

Drug interactions of Valtrex

No drug- drug interactions occurs in the valacyclovir treatment.





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Warning & precautions

Thrombocytopenia
This condition occurs during the therapy using with Valtrex, this may leads to death with chronic HIV-1 disease & bone marrow transplant. In this fatal condition treatment should be immediately stopped & monitor the manifestation due to this lethal case.

Acute renal failure
Use Valtrex 500mg in geriatric patients very carefully. Dosage reduction should be recommended for renal impaired patients. Patients who are receiving nephrotoxic drugs should be taken caution while getting Valtrex 500mg tablets. Patients have no sufficient hydration may leads to precipitation of acyclovir in renal tubules.

Central nervous system effects
In pediatric patients with or without renal impairment should be identified with nervous problems like agitation, hallucination, confusion, seizures during the treatment with Valtrex. In this condition therapy should be stopped.

Contraindications of Valtrex

Valtrex 500mg is highly contraindicated in patients with hypersensitivity reactions due to patients are contraindicated to the ingredients of Valtrex.


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