WELCOME TO Million Health Pharmaceuticals
Million-Health-Pharmaceuticals

Viroclear mechanism


The components in Viroclear tablets are involved in inhibiting non structural protein which is essential for viral multiplication. Sofosbuvir is a NS5B inhibitor, Viroclear is a directly acting anti-hepatitis C viral agent. Sofosbuvir leads to produce pharmacologically active uridine analog triphosphate by intracellular metabolism. Sofosbuvir is inserted into viral HCV DNA by NS5B polymerase and act as a chain terminator.

ADME property

The peak plasma concentration time of Sofosbuvir is 0.5 to 1 hour respectively. The effect of food with Viroclear tablet determines as; With moderate meal: Sofosbuvir increases to 60%; increases to 34% With high fat meal: Sofosbuvir increases to 78%; increases to 21% Flowing metabolite high serum time is between 2 to 4 hours

The human plasma protein bound; Sofosbuvir is 61 to 65%. The metabolism of Viroclear occurs; Sofosbuvir: cathepsin A, or carboxyl esterase The elimination of Viroclear occurs via;

SThe terminal half life of Viroclear tablets; Sofosbuvir: 0.5 hours; GS331007: 25 hours Elimination of Sofosbuvir in urine at 80%; feces at 14% ofosbuvir: Glomerular filtration, active tubular secretion


million-pharma-img

Brand : Viroclear
Ingredients : Sofosbuvir
Strength : 400mg
Manufactured : Abbott
Package : 28 Tablets

In adults

400mg of Viroclear The prescribed dose of Viroclear by blend with different meds; Considerate obtain with genotype I, IV, V or VI ceaseless hepatitis C viral disease: Viroclear is joined with ribavirin and peg interferon alfa ought to be taken as a once a day. Viroclear and ribavirin ought to be taken if there should be an occurrence of patients are bothersome to take peg interferon alfa.

Patients endured with genotype II ceaseless hepatitis C

Viroclear ought to be joined with ribavirin as a solitary dose Patients with genotype III hepatitis: Viroclear joined with ribavirin and peg interferon alfa and it ought to be taken as a solitary dose Generally Viroclear with ribavirin ought to be taken as single dose In liver transplantation: Viroclear ought to be simultaneously utilized with ribavirin as a single dose until liver transmission.

In pediatric

The usual dose Viroclear tablet for the children at age 12 or weight of at least 35kg; Without cirrhosis or with child Pugh A or compensated in patients: One tablet of Viroclear should be combined with weight based ribavirin as a single dose given for 12 weeks. For the patients with decompensated cirrhosis: Combine with ribavirin for 24 weeks the patients should be used One tablet The dosage of ribavirin; Based on body weight of the patients, the dosage of ribavirin should be recommended. < 75kg given 1000mg of ribavirin. At least 75kg given 1200mg of ribavirin. Ribavirin must be administered with food. Dosage adjustment should not be recommended in renal and hepatic impairment patients.

Viroclear causes undesirable effects

Headache Fatigue Nausea Asthenia Insomnia Anemia HBV reactivation Elevation of lipase & amylase levels Elevation of creatine kinase Cardiac disorder like bradycardia while concomitant with amiodarone Angioedema Skin rashes

Viroclear precautions

Exposure of hepatitis B viral infection occurs in HBV/HCV co infections Serious symptomatic bradycardia while concomitant with amiodarone Risk of depletion of therapeutic effect occurs due to combination of Viroclear with P-gp inducers or CYP3A4 inducers Fetal adverse occurs while concomitant with ribavirin For all these conditions, withhold or discontinue the therapy with Viroclear tablets.



million-pharma-book1

Viroclear drug interaction

Viroclear is a substrate of P-gp and BCRP transporters. While utilizing Viroclear with P-gp or BCRP solid inducers like rifampicin or st Johns wort may causes diminishing the plasma convergence of Viroclear . Accordingly the outcomes consumption of restorative impact of Viroclear Viroclear co organization with P-gp or BCRP inhibitors, causes expanding the plasma convergence of Viroclear Viroclear with comforting medication like modafinil causes diminishing the impact of grouping of Viroclear .

While joining with Viroclear with amiodarone, no impact of fixation happens yet symptomatic bradycardia happens Viroclear with vitamin K rival, vary the impact of vitamin K adversary Viroclear with anticonvulsants like phenytoin, Phenobarbital or carbamazepine causes diminishing the impact of Viroclear Viroclear with hostile to mycobacterials causes consumption essentially of grouping of Viroclear

Viroclear contraindicated to

Viroclear is contraindicated to patients who are taking in combination with ribavirin. Ribavirin is contraindicated to pregnancy condition.




abdominal pain
abdominal pain
concluded as death
concluded as death
dark urine
dark urine
fatigue
fatigue
flu like syndrome
flu like syndrome
loss of apetite
loss of apetite
loss of weight
loss of weight


Quick Contact





Prescription upload









Top Products



PRESCRIPTION


Millionpharma.com , a fully licensed and regulated pharmacy medicine, takes all precautions to strictly abide by the laws and regulations set forth in the dispensing of prescription medications. By placing the order for your prescription medicines, you acknowledge and accept the following terms regarding the purchase of any prescription medicines.

Millionpharma.com will not dispense any prescription medication without a valid prescription from a licensed physician.

If you are ordering prescription medication(s), you hereby confirm that you will send us a scanned copy of your valid prescription(s) via email, fax, Whatsapp, or by post, and this prescription shall then be subject to the scrutiny of and approval by our qualified Pharmacists.

The drug information provided in the Millionpharma.com is for informative purposes only and this Website is not intended to provide diagnosis, treatment or medical advice. We are not liable for any adverse effects or harm to you as a result of your reliance on the information in the Website.

Millionpharma.com requires either the User or Customer or the Caregiver to confirm he/she is completely aware of the indications, side effects, drug interactions, effects of missed dose or overdose of the medicines he/she orders from us. It is imperative to seek professional advice from your physician before purchasing or consuming any medicine from Millionpharma.com

At Millionpharma.com , a Caregiver can order prescription medicines on your behalf.



Disclaimer


This information should not be used to decide whether or not to take this Product or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this Product . It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this product.