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Virovir 250mg tablets is a prodrug form of penciclovir which are a nucleoside associated DNA polymerase inhibitor indicated for Immunocompetent Adult Patients Herpes labialis (cold sores): Virovir 250mg indicated for the treatment of recurrent episodes of herpes Labialis. Virovir 250mg used to treatment of recurrent episodes of Genital herpesand used for Suppressive therapy of recurrent episodes. Virovir 250mg is indicated for the treatment of Herpes zoster (shingles) For HIV-Infected Adult Patients, Virovir 250mg is indicated for the treatment of recurrent episodes of orolabial or genital herpes

Famciclovir readily go through biotransformation to penciclovir, which has preventory activity against HSV types 1 (HSV-1) and 2 (HSV-2), varicella-zoster virus (VZV). Thymidine kinase then add phosphorus group to penciclovir to a monophosphate form, which is then converted to penciclovir triphosphate. This blocks HSV-2 DNA polymerase by competing with deoxyguanosine triphosphate, thus prohibiting herpes viral DNA synthesis and multiplication.




PHARMACOKINETICS

Absorption

Fastly absorbed from the GI tract. The Virovir 250mg has Bioavailability: 77% (penciclovir) and Time to peak plasma concentration 1 hr. Food may delay absorption.

Distribution

Plasma protein binding of Virovir 250mg is <20%.

Metabolism

changed to penciclovir through deacetylation and oxidation.

Elimination

Virovir: excreted through urine (73%); faces (27%). Elimination half-life of Virovir: 1.6-3 hr.

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Brand : Virovir
Ingredients : Famciclovir
Strength : 250mg
Manufactured : FDC Ltd
Dosage Form : Tablet

The recommended dose in Adult for tablet Virovir

The patients suffering with Herpes Simplex – Suppression

The usual dose is 250mg twice a day orally for Immunocompetent patients. The usual dose is 500mg twice a day orally for HIV- Infected patients.

The patients suffering with Herpes Zoster

Dose prescribed is 500mg every 8 hours for 7 days orally.

The patients suffering with Herpes Simplex Labialis

Recurrent herpes labalis: 1500mg single dose orally.

The patients suffering with Herpes Simplex – Mucocutaneous / immunocompetent Host

The dose is 250mg administrated 3 times a day given orally for 7 to 10 days. The recommended dose for Relapsed episodes is1000mg twice a day for 1 day orally rather 125mg twice a day orally for 5 days.

The patients suffering with Herpes Simplex – Mucocutaneous / immunocompromised Host

Relapsed episodes prescribed dose is 500mg twice a day for 7 days.

OVERDOSAGE

Virovir was well tolerated, if it occurs provide supportive and symptomatic treatment should be given as appropriately.

Less common side effects of Virovir 250mg

• Mood or mental changes
• Hives or welts
• Itching skin
• Bloated, full feeling
• Excess air or gas in the stomach or intestines
• Redness of skin

More common side effects of Virovir 250mg

• High bleeding
• Headache
• Diarrhea
• Cramps

Incident not known side effects of Virovir 250mg

• Black stools
• Bleeding gums
• Blistering, peeling of the skin
• Dizziness
• Joint or muscle pain
• Pinpoint red spots on the skin
• Yellow eyes or skin
• Sores, ulcers or white spot in the mouth or on the lips.





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DRUG INTERACTION

Concomitant use of digoxin with Virovir will slightly increase the digoxin in your blood. Famciclovir combination with probenecid will raise the level of Famciclovir in your blood and increase side effects.

PRECAUTION

Susceptible to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.

Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While takingVirovir treatment If you become pregnant, discuss with doctor about the condition. Virovir 250mg may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.

MISSED DOSE

Immediately administer the medicine as you remember, If you missed any dose.If next dose time reaches swap the missed dose and continue the regular schedule. avoid taking double dose at a time. Please consult the doctor for further details.


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