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ADME process


Maximum plasma concentration time is almost 3 hours.


Raltegravir is largely bound to human serum protein by 83%. It is distributed in red blood cells at minor range.


Majorly in liver metabolism of Zepdon is occurs


The elimination route of Raltegravir is occurs through feces & urine. The terminal half life period of Raltegravir is 9 hours.


Brand : Zepdon
Ingredients : Raltegravir
Strength : 400mg
Manufactured : Cipla
Package : 60 Tablets


Zepdon tablet should be administered with or without food. In adult, the prescribed dose of Zepdon is 400mg should be administered as a two times a day. In pediatrics; 12 years or older: The prescribed dose is 400mg of Zepdon should be administered as two times aaday. 6 to less than 12 years of age: At least 25kg: One tablet of Zepdon should be taken orally as two times a day ≥ 40kg: 400mg of Zepdon should be administered two times a day


The maximum dose of Zepdon is 1600mg as a single dose The maximum dose of Zepdon is 800mg as two times a day. In case of over dosage of Zepdon patient must be; Initiate with supportive measures and Eliminate the unabsorbed dose from GI tract Monitor the manifestation occurs due to over dosage

Side effects in zepdon

Insomnia Abnormal dreams Fatigue Neutropenia Anemia Decreased in platelets count Elevation of blood glucose level Increased bilirubin Increased serum AST, ALT Increased alkaline phosphatase Headache Nausea Asthenia Abdominal pain Gastritis Hepatitis Hypersensitivity Herpes zoster Dizziness Renal failure Suicidal ideation Rash Stevens Johnson syndrome

Severe skin reactions & anaphylactic reactions

Skin reactions like Stevens Johnson syndrome & toxic epidermal necrolysis are some of fatal cases occur. In case of life threatening condition, therapy should be discontinue and provide the general supportive therapy. Clinical status should be appropriately monitored for reducing the manifestations.

Immune reconstitution syndrome

This fatal condition is commonly occurred in patients who are receiving anti-retroviral treatment. Provide safety measures In severe condition, stop the treatment.


Raltegravir chewable tablets are containing a component like phenylalanine (aspartame component) which is responsible for this fatal case.


Drug- drug interaction

Zepdon combined with atazanavir causes increasing the concentration of Raltegravir. Raltegravir is not inhibits the CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 or 3A. Raltegravir not prohibits the P-gp mediated transport. Zepdon tablets are combined with rifampin causes depletion of plasma concentration of Raltegravir.

In case of this combination, the dose of Zepdon should be increased for reducing this adverse. Zepdon interaction with atazanavir/ritonavir, causes increasing concentration of Raltegravir Zepdon tablets are concurrently used with efavirenz leads to cause decreasing the concentration of Raltegravir.

Zepdon with efavirine causes decreasing concentration of Raltegravir Zepdon tablets combined with tipranavir/ritonavir, causes depleting the effect of concentration of Raltegravir. Co administration of Zepdon with gastric regulators should be avoided, because this combination leads to increase the effect of concentration of Raltegravir.

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