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The absorption of zidovudine is occurs very quickly. The oral bioavailability of Zidine ;


The Zidine is highly distributed in body. The component of Zidine tablets are binding to human plasma protein with the range of <38% for zidovudine. The binding plasma ratio of Zidine is low.


Zidovudine is undergoes metabolism by glucoronide conjugation.


Zidine is undergoes hepatic metabolism elimination. Route of elimination of zidovudine is 29% through urine; 45% excreted as zidovudine metabolite. The zidovudine half life period of is 0.5 to 3 hours. The renal creatinine clearance of zidovudine is 0.34 plus or minus 0.05 L/hr/kg.


Brand : Zidine
Ingredients : Zidovudine
Strength : 300mg
Manufactured : Emcure
Package : 30 Tablets

In adult

The recommended dose is 300mg Zidovudine capsules for twice daily in combination with other antiretroviral.

Pediatric patients (age of 4 weeks to < 18 years)

The dose is usually calculated based on body weight(kg) and not to be exceed the usual adult dose The patient body weight 4 to <9 = 24mg/kg/day given as 12mg/kg twice daily; 8mg/kg three times daily >9 to >30 = 18mg/kg/day given as 9mg/kg for twice daily ; 6mg/kg three times daily ≥ 30 = 600mg/day given as 300mg for twice daily ; 200mg for three times daily

Prevention of maternal-fetal HIV-1 transmission

Maternal dosing: Before start of labor administrate 100mg orally 5 times /day. During labor and delivery, administered 2mg/kg IV over 1 hour followed by a continuous IV infusion of 1mg/kg/hr until clamping of umbicalcord Neonatal dosing After birth Dosing within 12 hours and continue through 6 weeks of age Oral route = 8mg/kg/day total daily dose but given as 2mg/kg for every 6 hours Intrevenous route = 6mg/kg/day total daily dose but given as 1.5mg/kg infused over 30min, every 6hrs Zidine tablet should be administered with or without food.

Over dosage

The over dosage of Zidine should be treated by undergoing hemodialysis. Hemodialysis helps to remove the content of zidovudine from the body. The acute over dosage condition, causes adverse effects like fatigue, headache, vomiting & hematological disturbance. Provide supportive measures.

The most common side effects

Headache Malaise Fatigue Anorexia Loss of appetite Dyspepsia Abdominal cramps Neuropathy Insomnia Dizziness Depression Nasal signs Cough Rashes Musculoskeletal pain Myalgia Arthralgia

Lab abnormalities

Neutropenia Anemia Thrombocytopenia Elevated AST, ALT Hyperbilirubinaemia Increased amylase Fat redistribution Cardiomyopathy Gynecomastia Lymphadenopathy Splenomegaly Wheezing Alopecia Erythema multiforme Stevens Johnson’s syndrome

The most serious adverse effects are

Hematological toxicity Symptomatic myopathy Lactic acidosis or hepatomegaly with steatosis Aggravation of hepatitis B Hepatic decompensated cirrhosis in patient with HCV/HIV co infection. Aggravation of anemia due to patients who are co infected with HIV-1/HCV getting ribavirin & zidovudine. Pancreatitis Immune reconstitution syndrome Lipoatrophy


Hematological toxicity, lactic acidosis or hepatomegaly with steatosis & aggravation of hepatitis B infection; these are all possible adverse occurred during or after completion of therapy with Zidine.

Hematological toxic

Periodic blood cells count should be taken. In case of neutropenia or thrombocytopenia, Zidine treatment should be postponed.

Lactic acidosis or hepatomegaly with steatosis

This condition may leads to produce fatal cases, majorly in women. The most common adverse effect is obesity In severe condition treatment should be discontinued.

Ribavirin based therapy

Zidine combined with ribavirin causes hematological problems in severe condition. Avoid the concomitant use Check the blood cell count during the therapy if necessary. In Immune reconstitution syndrome, Zidine tablets should be

Hepatitis B co infection

To overcome the post treatment aggravation of hepatitis infection, patient should be monitored with hepatic function frequently after completion of treatment. The incidence of lamivudine resistance caused hepatitis infection; the potency of lamivudine in patient with HIV-1 HCV co infection has not been evaluated. The concurrent use of lamivudine may leads to cause this type of infection. discontinued



Drugs which are opposing the activity of zidovudine; The combination of zidovudine with some drugs produces antagonist effects, like Stavudine Doxorubicin Nucleoside analogues like ribavirin

Zidine tablets are concurrent use with ribavirin, Ganciclovir, interferon alfa or other drugs may elevate the hematological toxicity effect of zidovudine. Avoid this concomitant treatment. Avoid this combination therapy. Zidine should not be combined with Zalcitabine which may alters t or inhibits the intracellular phosphorylation of one another.


Anaphylactic reaction may occur in the patient are contraindicated to the component present in Zidine tablets.

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