Shivtaf 25mg (Tenofovir Alafenamide 25mg) – Overview

Shivtaf 25mg is an antiviral medication primarily used for the treatment Chronic Hepatitis B and as a part of combination therapy for HIV-1 infection. As a prodrug of tenofovir, it delivers the active compound more efficiently with fewer side effects compared to earlier formulations.

Medical Uses / Indications

• Chronic hepatitis B virus (HBV) infection in adults and adolescents
• HIV-1 infection (as part of a combination antiretroviral regimen)

How Shivtaf 25mg Works (Mechanism of Action)

Shivtaf is converted in the body to tenofovir, which inhibits viral reverse transcriptase, an enzyme necessary for viral replication. This prevents the virus from multiplying within infected cells.

Dosage & Administration

• For chronic hepatitis B: 25mg orally once daily, with or without food
• For HIV-1: Dosage and administration depend on the specific combination regimen used
• Always follow the prescribing healthcare provider’s instructions

Possible Side Effects

• Nausea
• Headache
• Fatigue
• Abdominal pain

• Lactic acidosis
• Severe liver problems
• Kidney problems
• Bone loss

Drug Interactions

• May interact with anticonvulsants, certain antivirals, and drugs affecting kidney function
• Always inform your healthcare provider about all medications and supplements you are taking

Precautions

• Use with caution in patients with kidney or liver impairment
• Regular monitoring of kidney and liver function may be needed
• Not recommended during pregnancy or breastfeeding without medical advice

Storage & Handling

• Store at room temperature (20-25°C or 68-77°F)
• Keep in the original container, tightly closed
• Protect from moisture and light

Missed Dose

• Take the missed dose as soon as you remember
• If it is almost time for your next dose, skip the missed dose—do not double up
• Continue with your regular dosing schedule