Trioday Tablet (Efavirenz 600mg, Lamivudine 300mg and Tenofovir Disoproxil Fumarate 300mg) – Overview

Trioday Tablet contains Efavirenz 600mg, Lamivudine 300mg, and Tenofovir Disoproxil Fumarate 300mg is a fixed-dose combination medication used to treat HIV infection in adults and adolescents. This medication contains three antiretroviral agents that work together to reduce the amount of HIV in the body and improve immune function.

Medical Uses / Indications

This combination is indicated for the treatment of HIV-1 infection in adults and adolescents aged 12 years and older. It is usually prescribed as part of antiretroviral therapy (ART) to help control HIV infection.

How Trioday tablet Works (Mechanism of Action)

• Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI), blocking the reverse transcriptase enzyme needed for viral replication.
• Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) that blocks reverse transcriptase, preventing viral RNA from being converted into DNA.
• Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor (NtRTI), which also blocks reverse transcriptase and prevents viral replication.

Together, these drugs inhibit HIV replication at different stages, reducing viral load and slowing the progression of the disease.

Dosage & Administration

The usual adult dose is one tablet (Efavirenz 600mg, Lamivudine 300mg, Tenofovir Disoproxil Fumarate 300mg) taken once daily, preferably on an empty stomach at bedtime to minimize side effects. Dosage may be adjusted by your healthcare provider based on your specific condition.

Possible Side Effects

• Common: Dizziness, headache, trouble sleeping, tiredness, rash, diarrhea, nausea, and vomiting.
• Serious: Severe rash, liver problems (jaundice, dark urine), psychiatric symptoms (depression, mood changes, suicidal thoughts), lactic acidosis, kidney problems, and severe allergic reactions. Contact your healthcare provider if you notice any serious symptoms.

 Drug Interactions

This combination may interact with other medicines, including other antiretrovirals, anticonvulsants, antifungal medications, antibiotics, and certain herbal products (e.g., St. John’s Wort). Inform your doctor about all medicines you are taking before starting this medication.

Precautions

• Not recommended for use during pregnancy unless advised by your doctor.
• Regular monitoring of kidney and liver function is required.
• Use with caution in patients with pre-existing liver or kidney conditions.
• Avoid alcohol and recreational drugs, as they may increase the risk of side effects.

Storage & Handling

Store at room temperature (20°C to 25°C), away from moisture and direct sunlight. Keep out of reach of children.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.