Hepcinat Plus 400mg/60mg Tablet (Sofosbuvir 400mg & Daclatasvir 60mg) – Overview

Medical Uses / Indications

• Treatment of chronic hepatitis C infection (genotypes 1, 3, and others as per clinical guidelines)
• Often used in patients without cirrhosis or with compensated cirrhosis
• May be used in combination with other antiviral agents

How Hepcinat Plus tablet Works (Mechanism of Action)

• Sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase, essential for viral replication
• Daclatasvir is an inhibitor of HCV NS5A, a protein required for viral RNA replication and assembly
• The combination blocks two key steps in the viral life cycle, leading to a sustained virologic response

Dosage & Administration

• The typical dose is one tablet (400mg Sofosbuvir + 60mg Daclatasvir) taken orally once daily
• Take at the same time each day, with or without food
• Duration of therapy is usually 12 to 24 weeks depending on patient factors and viral genotype
• Follow your doctor’s instructions carefully

Possible Side Effects

• Fatigue
• Headache
• Nausea
• Insomnia
• Anemia
• Rash or allergic reactions (rare but serious)
• Consult your healthcare provider if you experience severe symptoms such as difficulty breathing, swelling, or jaundice

Drug Interactions

• May interact with anticonvulsants (e.g., phenytoin, carbamazepine)
• Antacids and other medicines that affect stomach pH can alter absorption
• Some antibiotics and antiretroviral drugs may affect efficacy
• Inform your healthcare provider of all medications and supplements you are taking

Precautions

• • Not recommended in patients with severe kidney or liver impairment unless prescribed by a specialist
  • Use with caution in pregnant or breastfeeding women
  • Effective contraception should be used during treatment if applicable
  • Regular monitoring of liver function and viral load is recommended

Storage & Handling

• Store at room temperature (15–30°C)
• Keep away from moisture and direct sunlight
• Keep out of reach of children

Missed Dose

• If you miss a dose, take it as soon as you remember
• If it is almost time for your next dose, skip the missed dose—do not double up
• Continue with your regular dosing schedule
• Consult your healthcare provider if you miss multiple doses