Ledihep 400mg/90mg Tablet (Sofosbuvir 400mg & Ledipasvir 90mg) – Overview

Ledihep tablet is a prescription medication primarily used in the management of chronic hepatitis C virus (HCV) infection. It is a combination of two antiviral agents, Ledipasvir 90mg and Sofosbuvir 400mg, which work together to interfere with the viral replication process.

Medical Uses / Indications

Ledihep tablet is indicated for the treatment of chronic hepatitis C infection in adults. It may be used as part of a complete treatment regimen for those with specific genotypes of the virus, helping to achieve sustained virologic response (SVR).

How Ledihep tablet Works (Mechanism of Action)

Ledihep tablet contains Ledipasvir 90mg and Sofosbuvir 400mg. Ledipasvir acts as an inhibitor of the HCV NS5A protein, which is essential for viral replication and assembly. Sofosbuvir, on the other hand, is a nucleotide analog that inhibits the HCV NS5B polymerase, preventing viral RNA synthesis. Together, they effectively halt the virus’s ability to replicate and spread.

Dosage & Administration

The recommended dosage of Ledihep tablet is one tablet taken orally once daily, with or without food. Treatment duration may vary based on the specific HCV genotype and patient history. It is crucial to adhere to the prescribed regimen to maximize the chances of a successful treatment outcome.

Possible Side Effects

Common side effects may include:

• Fatigue
• Headache
• Nausea
• Insomnia Serious

side effects can include:

• Liver problems (e.g., jaundice, dark urine)
• Severe allergic reactions (e.g., rash, itching, swelling)
• Heart rhythm issues

Patients should contact their healthcare provider immediately if they experience any severe side effects.

Drug Interactions

Ledihep tablet may interact with certain medications, including:

• Anticonvulsants (e.g., carbamazepine, phenytoin)
• HIV medications (e.g., ritonavir)
• Some antifungals (e.g., ketoconazole)

It’s essential to inform the healthcare provider about all medications and supplements being taken to avoid potential interactions. 

Precautions

Before starting Ledihep tablet, patients should disclose their complete medical history, especially any liver problems, prior antiviral treatment, or allergies. It is also not recommended during pregnancy unless specifically advised by a healthcare professional.

Storage & Handling

Ledihep tablets should be stored at room temperature, away from moisture and direct sunlight. Keep out of reach of children. If the medication is past its expiration date, dispose of it properly and consult a pharmacist.

Missed Dose

If a dose of Ledihep tablet is missed, take it as soon as remembered. However, if it’s nearly time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take two doses at the same time to make up for the missed dose. Always consult a healthcare professional for more information and guidance regarding Ledifos treatment.