Nevir ER 400mg Tablet (Nevirapine ER 400mg) – Overview

Nevir ER 400mg tablet contain Nevirapine ER 400mg is an antiretroviral medication used in the treatment of Human Immunodeficiency Virus (HIV) infection. It belongs to the class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Medical Uses / Indications

Nevirapine is indicated for use in combination with other antiretroviral agents for the management of HIV-1 infection in adults and children. It is not a cure for HIV, but it helps to lower the viral load, maintain immune function, and reduce the risk of HIV-related illnesses.

How Nevir ER 400mg tablet Works (Mechanism of Action)

Nevirapine binds directly to reverse transcriptase, an enzyme essential for the replication of HIV. By inhibiting this enzyme it prevents the virus from multiplying in the body.

Dosage & Administration

Nevirapine Extended Release (ER) 400mg Tablets: The typical adult dose is one 400mg tablet taken orally once daily, after a 14-day lead-in period with immediate-release Nevirapine 200mg once daily. Nevirapine ER should be swallowed whole, not chewed, crushed, or split. It may be taken with or without food. Always take as prescribed and do not adjust your dose without consulting your healthcare provider.

Possible Side Effects

• Common: Rash, nausea, headache, fever, fatigue.
• Serious: Severe rash (Stevens-Johnson syndrome), liver toxicity (symptoms may include jaundice, dark urine, abdominal pain), hypersensitivity reactions. Seek medical attention for severe symptoms.

 Drug Interactions

Nevirapine may interact with other medications such as rifampicin, ketoconazole, oral contraceptives, and certain anticonvulsants. Always inform your healthcare provider about all medicines you take.

Precautions

• Monitor liver function before and during treatment.
• Discontinue if severe rash or liver problems develop.
• Use with caution in patients with pre-existing liver disease.
• Not recommended for post-exposure prophylaxis.

Storage & Handling

• Store at room temperature (20–25°C or 68–77°F).
• Keep out of reach of children.
• Protect from moisture and light.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.