Sofovir 400mg (Sofosbuvir 400mg) – Overview

Medical Uses / Indications

• Indicated for:
  • Chronic HCV infection (adults and certain pediatric patients, depending on guidelines)
  • Used in combination with other antiviral agents (not as monotherapy)
• HCV Genotypes:
  • Broad activity against multiple HCV genotypes (1, 2, 3, 4, 5, 6)
• Treatment Goals:
  • Achieve sustained virologic response (SVR), considered a cure of hepatitis C

How Sofovir Works (Mechanism of Action)

Dosage & Administration

• • Usual Dose:
    • 400mg orally, once daily, with or without food
  • Duration:
    • Typically 12 weeks (may vary depending on genotype, combination regimen, and patient factors)
  • Combination Therapy:
    • Always used in combination with other antivirals (e.g., ledipasvir, velpatasvir, daclatasvir, or ribavirin)
  • Special Populations:
    • Dose adjustment not generally required for mild-to-moderate renal/hepatic impairment; consult guidelines for severe cases

Possible Side Effects

• Fatigue
• Headache
• Nausea
• Insomnia

• Severe allergic reactions (rare)
• Bradycardia (slow heart rate), especially when used with amiodarone
• Reactivation of hepatitis B in co-infected patients

Drug Interactions

• Strong inducers of P-glycoprotein:
  • May decrease sofosbuvir effectiveness (e.g., rifampin, St. John’s Wort)
• Amiodarone:
  • Risk of serious symptomatic bradycardia when coadministered; avoid use together
• Other DAAs and antivirals:
  • Consult specific combination regimens for interactions

Precautions

• • Not for monotherapy:
    • Always use with other antivirals
  • Hepatitis B co-infection:
    • Risk of HBV reactivation—screen before starting
  • Renal/Hepatic impairment:
    • Use with caution in severe impairment
  • Pregnancy & Breastfeeding:
    • Safety not well established; use only if clearly needed
  • Use in children:
    • Only as recommended by guidelines

Storage & Handling

• • Store at room temperature (20–25°C / 68–77°F)
  • Keep in the original container, tightly closed
  • Protect from moisture and light
  • Keep out of reach of children

Missed Dose

• • Take it as soon as you remember on the same day.
  • If it is almost time for your next dose, skip the missed dose—do not double up.
  • Continue with your regular dosing schedule.